Evidence map›Paper›PMID 42629571›Full record

ArticleActa neuropathologica communications2026

Overactivation of SHH signaling induces a cascade of dedifferentiation and oncogenesis in a new mouse model for choroid plexus carcinoma.

Levke-Sophie Peter, Lea Altendorf, Karoline Hack, Vanessa Thaden, Carolin Göbel, Beatrix Mahnke, Christian Krebs, Saskia-L Jauch-Speer, Uwe R Kordes, Denise Obrecht-Sturm and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Levke-Sophie PeterResearch Institute Children's Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistraße 52, Building N63, 20251, Hamburg, Germany.
Lea AltendorfResearch Institute Children's Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistraße 52, Building N63, 20251, Hamburg, Germany.
Karoline HackResearch Institute Children's Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistraße 52, Building N63, 20251, Hamburg, Germany.
Vanessa ThadenResearch Institute Children's Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistraße 52, Building N63, 20251, Hamburg, Germany.
Carolin GöbelResearch Institute Children's Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistraße 52, Building N63, 20251, Hamburg, Germany.
Beatrix MahnkeResearch Institute Children's Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistraße 52, Building N63, 20251, Hamburg, Germany.
Christian KrebsIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Saskia-L Jauch-SpeerIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Uwe R KordesDepartment of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Denise Obrecht-SturmDepartment of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Christian ThomasInstitute of Neuropathology, University Hospital Münster, Münster, Germany.
Ulrich Schüller *Research Institute Children's Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistraße 52, Building N63, 20251, Hamburg, Germany. u.schueller@uke.de.ORCID https://orcid.org/0000-0002-8731-1121
Melanie Schoof *Research Institute Children's Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistraße 52, Building N63, 20251, Hamburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Choroid Plexus tumors constitute 10-20% of brain tumors in infancy. Among these, Choroid Plexus Carcinomas (CPC) are highly aggressive and result in poor survival. Details on tumor initiation and oncogenic events remain largely unknown, aside from a high prevalence of TP53 mutations and marked chromosomal instability. We generated hGFAP-cre::lsl-MYCN::lsl-Gli2(N)::Tp53

Indexed as

CarcinogenesisCarcinomaCell DedifferentiationChoroid Plexus NeoplasmsHedgehog ProteinsSignal TransductionAnimalsChoroid PlexusDisease Models, AnimalMiceMice, TransgenicTumor Suppressor Protein p53Zinc Finger Protein Gli2Gli2 protein, mouseHedgehog ProteinsShh protein, mouseTrp53 protein, mouseTumor Suppressor Protein p53Zinc Finger Protein Gli2Choroid Plexus carcinomaDedifferentiationMouse modelSonic Hedgehog signalingSpatial transcriptomics

Identifiers

PMID42629571
PMCPMC13499314

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.