ArticleJournal of molecular histology2026
Anti-inflammatory and protective effects of Aloe vera on intestinal function in zebrafish.
Article in Journal of molecular histology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Aloe vera and its polysaccharides can reduce inflammation and support intestinal barrier repair, offering potential benefits for inflammatory bowel disease (IBD). Using a zebrafish model of TNBS-induced intestinal inflammation, we evaluated the anti-inflammatory effects of Aloe vera gel (Aloe-S0) and its polysaccharide-rich fraction (APS-CPIC). Transcriptomic analysis was performed to explore mechanisms of action. Aloe-S0 and APS-CPIC reduced inflammation and mucosal damage, enhanced goblet cell numbers, restored the mucus barrier, and improved intestinal motility. Mechanistically, treatment downregulated pro-inflammatory genes (prkcq, sfmbt1, tyk2) and upregulated jag2b. Protein expression changes (reduced PRKCQ, SFMBT1, TYK2; increased JAG2) supported these findings. Aloe-S0 and APS-CPIC exert protective effects against intestinal inflammation in zebrafish, highlighting their therapeutic potential for IBD.
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