Evidence map›Paper›PMID 42629398›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Weighted and unweighted comorbidity burden for predicting three-year neurodevelopment in extremely preterm infants: A nationwide cohort study.

Shuji Ishida, Hidehiko Nakanishi, Izumi Iitsuka, Moe Matsuura, Yoshie Oosaki, Maki Iwai, Rika Sekiya, Kohei Kawada, Yukako Kosaka, Ayano Yamaguchi and 2 more

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Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Shuji IshidaDepartment of Pediatrics, Kitasato University, Kanagawa, Japan. s-ishida@kitasato-u.ac.jp.ORCID http://orcid.org/0000-0002-5050-1247
Hidehiko NakanishiDepartment of Pediatrics, Kitasato University, Kanagawa, Japan.ORCID http://orcid.org/0000-0001-5768-3971
Izumi IitsukaDepartment of Pediatrics, Kitasato University, Kanagawa, Japan.
Moe MatsuuraDepartment of Pediatrics, Kitasato University, Kanagawa, Japan.
Yoshie OosakiDepartment of Pediatrics, Kitasato University, Kanagawa, Japan.
Maki IwaiDepartment of Pediatrics, Kitasato University, Kanagawa, Japan.
Rika SekiyaDepartment of Pediatrics, Kitasato University, Kanagawa, Japan.
Kohei KawadaDepartment of Pediatrics, Kitasato University, Kanagawa, Japan.ORCID http://orcid.org/0000-0002-9213-318X
Yukako KosakaDepartment of Pediatrics, Kitasato University, Kanagawa, Japan.
Ayano YamaguchiDepartment of Pediatrics, Kitasato University, Kanagawa, Japan.
Mari OokaDepartment of Pediatrics, Kitasato University, Kanagawa, Japan.
on behalf The Neonatal Research Network of Japan

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the prognostic utility of unweighted morbidity counts and weighted morbidity scores for predicting neurodevelopmental outcomes at 3 years in extremely preterm infants. STUDY

designThis retrospective cohort study used data from the Neonatal Research Network of Japan and included infants born at <28 weeks' gestation. Neurodevelopment at 3 years was assessed using developmental quotient and cerebral palsy. Cumulative morbidity burden was quantified using unweighted morbidity counts and weighted morbidity scores derived from log-odds ratios for severe impairment. Inverse probability weighting addressed incomplete follow-up.

resultsBoth unweighted morbidity counts and weighted morbidity scores were significantly associated with adverse neurodevelopmental outcomes. Unweighted morbidity counts demonstrated higher sensitivity for identifying any adverse outcome, whereas weighted morbidity scores showed high specificity (0.94) for severe impairment.

conclusionUnweighted morbidity counts and weighted morbidity scores provide complementary prognostic information and may improve risk stratification, follow-up prioritization, and family counseling for extremely preterm infants.

Identifiers

PMID42629398

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