Evidence map›Paper›PMID 42629350›Full record

Reviewnpj aging2026

How age and sex interaction is associated with immune aging with implications for vaccines and age-related autoimmunity.

Reza Gheitasi, Mahnaz Rezaei, Parvaneh Nafisi Fard, Daniela Roel, Sabine Baumgart, Diana Dudziak, Norman Rose, Simon M Petzinna, Thomas Kamradt, Carsten Watzl and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in npj aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Reza GheitasiClinic of Internal Medicine III, Oncology, Hematology, Rheumatology and Clinical Immunology, University Hospital Bonn, Bonn, Germany. reza.gheitasi@ukbonn.de.
Mahnaz RezaeiImmunodeficiency Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Parvaneh Nafisi FardDivision of Molecular Cell Biology, Institute of Theoretical Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Daniela RoelInstitute of Infectious Diseases and Infection Control, Jena University Hospital/Friedrich Schiller University, Jena, Germany.
Sabine BaumgartInstitute of Immunology, Jena University Hospital/Friedrich Schiller University, Jena, Germany.
Diana DudziakInstitute of Immunology, Jena University Hospital/Friedrich Schiller University, Jena, Germany.
Norman RoseInstitute of Infectious Diseases and Infection Control, Jena University Hospital/Friedrich Schiller University, Jena, Germany.
Simon M PetzinnaClinic of Internal Medicine III, Oncology, Hematology, Rheumatology and Clinical Immunology, University Hospital Bonn, Bonn, Germany.
Thomas KamradtInstitute of Immunology, Jena University Hospital/Friedrich Schiller University, Jena, Germany.
Carsten WatzlDepartment of Immunology, Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund (IfADo), Dortmund, Germany.
Mathias W PletzInstitute of Infectious Diseases and Infection Control, Jena University Hospital/Friedrich Schiller University, Jena, Germany.
Valentin S SchäferClinic of Internal Medicine III, Oncology, Hematology, Rheumatology and Clinical Immunology, University Hospital Bonn, Bonn, Germany.

Funding

Thuringian Ministry for Economic Affairs, Science and Digital Society (TMWWDG) SV-Kapitel 82 30 Titel 68205 # 5526/32-4-2
6 · The paper itself

Abstract

Immunosenescence is not a uniform decline but a trajectory shaped jointly by age and sex. Using continuous high-dimensional immunophenotyping, we show that aging T cells accumulate a senescent signature of CD28 loss and CD57 gain, and that males reach an inverted CD4:CD8 ratio earlier and more severely than females. We argue that age-by-sex stratification should guide vaccination and geroprotective strategies in an aging population.

Identifiers

PMID42629350
PMCPMC13498583

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.