Comparative evaluation of the immunogenicity and protective efficacy of gamma-irradiated Salmonella Gallinarum (γ-SG), SG ΔpurB mutant, and their combined vaccine formulations in chicken.

Isha Farooq, Masham Mukhtar, Hassaan Bin Aslam, Muhammad Suleman, Maham Nawazish, Michael McClelland, Aamir Ghafoor

Abstract readComparative Study

In one paragraph

Article in Microbial pathogenesis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Isha FarooqDepartment of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan. Electronic address: farooqisha62@gmail.com.

Masham MukhtarDepartment of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan. Electronic address: Masham.mukhtar@uvas.edu.pk.

Hassaan Bin AslamDepartment of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan. Electronic address: hassaan.aslam@uvas.edu.pk.

Muhammad SulemanDepartment of Pathology, University of Veterinary and Animal Sciences, Lahore, Pakistan. Electronic address: Muhammad.suleman@uvas.edu.pk.

Maham NawazishDepartment of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan. Electronic address: mahamnawazish1@gmail.com.

Michael McClellandDepartment of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA, United States. Electronic address: mmcclell@uci.edu.

Aamir GhafoorDepartment of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan. Electronic address: aamir.ghafoor@uvas.edu.pk.

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026

$57.9M

NCI NIH HHS P30 CA062203

6 · The paper itself

Abstract

Salmonella Gallinarum (SG), continues to impose economic losses in poultry, highlighting the need for better vaccination strategies to improve immunogenicity and protection. This study comparatively evaluated the immunogenicity and protective efficacy of a γ-SG vaccine, an SG ΔpurB live attenuated mutant, and their combined vaccine formulations in chickens. Five groups of chickens (A-E) were administered with SG ΔpurB IM (2.0 × 10

Indexed as

Gamma RaysImmunogenicity, VaccinePoultry DiseasesSalmonellaSalmonella Infections, AnimalSalmonella VaccinesAnimalsAntibodies, BacterialCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesChickensVaccinationVaccine EfficacyVaccines, AttenuatedVaccines, CombinedAntibodies, BacterialSalmonella VaccinesVaccines, AttenuatedVaccines, CombinedCD4(+) T cellsCD8(+) T cellsCombination vaccinationFowl typhoidIgG responseSG ΔpurBγ-SG

Identifiers

PMID42628885

DOI10.1016/j.micpath.2026.108797

PMCPMC13614706

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.