Evidence map›Paper›PMID 42628701›Full record

ArticleBrain, behavior, and immunity2026

The MR1/MAIT cell axis has limited effects on the start of tau pathology in a mouse model of tauopathy.

Season K Wyatt-Johnson, Sujal Joshi, Maggie Blair, Jay M Desai, S M Mansour Haeryfar, Cristian A Lasagna-Reeves, Randy R Brutkiewicz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Season K Wyatt-JohnsonDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: seasjohn@iu.edu.
Sujal JoshiDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
Maggie BlairDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Jay M DesaiDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
S M Mansour HaeryfarDepartment of Microbiology and Immunology, Western University, London, Ontario, Canada; Division of General Surgery, Department of Surgery, Western University, London, Ontario, Canada; Division of Clinical Immunology and Allergy, Department of Medicine, Western University, London, Ontario, Canada.
Cristian A Lasagna-ReevesStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Neurology, Baylor College of Medicine, Houston, TX, USA.
Randy R BrutkiewiczDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: rbrutkie@iu.edu.

Funding

MR1/MAIT cell axis-mediated regulation of inflammatory responsesR01AG092565 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI Randy R Brutkiewicz · 2026 to 2026
$625k
NIA NIH HHS R01 AG092565
6 · The paper itself

Abstract

Immunity impacts all aspects of Alzheimer's disease (AD) pathology. Previously, we found improved pathology and cognition in the amyloid-focused 5XFAD mouse model deficient in the innate immune cell axis consisting of the innate-like mucosal-associated invariant T (MAIT) cells and the MHC class I-like antigen-presenting molecule they recognize, MR1. However, little is known about how a lack of the MR1/MAIT cell axis impacts cognition and whether an increased abundance of MAIT cells impacts pathology and cognition in the tau-focused PS19 mouse model. We crossed PS19 mice onto an MR1 KO background, resulting in a lack of both MR1 and MAIT cells, and alternatively, onto MAIT

Indexed as

Alzheimer’s diseaseAstrocytesInnate immunityMicrogliaTau

Identifiers

PMID42628701
PMCPMC13639847

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.