Evidence map›Paper›PMID 42628507›Full record

ArticleSexually transmitted diseases2026

Looking down the road: development and distribution of a future syphilis vaccine.

Arlene C Seña, Lorenzo Giacani, Caroline E Cameron, Melissa J Caimano, Michael Marks, Mathew A Beale, Linda Grillova, Suzanne Day, Kimberly Workowski, Adele Schwartz-Benzaken and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sexually transmitted diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Arlene C SeñaDepartment of Medicine, Division of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, USA.
Lorenzo GiacaniDepartment of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, USA.
Caroline E CameronDepartment of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, USA.
Melissa J CaimanoDepartments of Pediatrics and, UConn Health, Farmington, Connecticut, USA.
Michael MarksLondon School of Hygiene & Tropical Medicine, London, UK.
Mathew A BealeParasites and Microbes Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Linda GrillovaParasites and Microbes Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Suzanne DayDepartment of Medicine, Division of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, USA.
Kimberly WorkowskiDepartment of Medicine, Emory University, Atlanta, Georgia, USA.
Adele Schwartz-BenzakenAIDS Healthcare Foundation Brazil, Manaus, Brazil.
Kelly L HawleyDepartment of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, USA.

Funding

Prevalence of syphilis and other sexually transmitted infections in men and transgender women who have sex with men in Cali, ColombiaU19AI144177 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI SALAZAR, JUAN C · 2019 to 2023
$11.2M
University of Washington (UW) Sexually Transmitted Infections (STI) Cooperative Research Center (CRC) - Syphilis Vaccine to Protect against Local and Disseminated T. pallidum InfectionU19AI144133 · NIAID · UNIVERSITY OF WASHINGTON · PI WALD, ANNA · 2019 to 2023
$10.6M
A Global Syphilis Vaccine Targeting Outer Membrane Proteins of Treponema pallidumU01AI182179 · NIAID · DUKE UNIVERSITY · PI Michael Anthony Moody, Justin D Radolf · 2024 to 2026
$6.9M
Development of a Chimeric Syphilis Vaccine Candidate to Combat Local, Disseminated and Congenital Syphilis InfectionU01AI182035 · NIAID · UNIVERSITY OF VICTORIA · PI CAROLINE E CAMERON, Lorenzo Giacani · 2024 to 2026
$4.8M
Extracellular Matrix Adhesins of Treponema pallidumR37AI051334 · NIAID · UNIVERSITY OF VICTORIA · PI CAROLINE E CAMERON · 2019 to 2026
$2.3M
Nutrient acquisition and cyclic nucleotide signaling in Treponema pallidum as underpinnings of stealth pathogenicityR21AI194255 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CAIMANO, MELISSA J, RADOLF, JUSTIN D · 2025 to 2025
$458k
Bill & Melinda Gates Foundation INV-007206Bill & Melinda Gates Foundation INV-035896NIAID NIH HHS R21 AI194255NIAID NIH HHS R37 AI051334NIAID NIH HHS U01 AI182035NIAID NIH HHS U01 AI182179NIAID NIH HHS U19 AI144133NIAID NIH HHS U19 AI144177Wellcome Trust
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

syphilisvaccine development

Identifiers

PMID42628507
PMCPMC13648105

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.