Evidence map›Paper›PMID 42627920›Full record

ArticleScience advances2026

Constitutively active glucagon receptor (GCGR) physiologically regulates body temperature in lizards.

Songsong Liu, Qingqing Ren, Shanshan Lai, Xiangying Xiang, Yongjie Huang, Qingqing Wang, Qiujinman Mao, Xiaofei Yan, Ao Dai, Najeeb Ullah and 6 more

Abstract read
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Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Songsong LiuJiangsu Key Laboratory for Biodiversity and Biotechnology, State Key Laboratory of Microbial Technology, College of Life Sciences, Nanjing Normal University, Nanjing, PR China.ORCID 0009-0007-5253-3211
Qingqing RenJiangsu Key Laboratory for Biodiversity and Biotechnology, State Key Laboratory of Microbial Technology, College of Life Sciences, Nanjing Normal University, Nanjing, PR China.
Shanshan LaiJiangsu Key Laboratory for Biodiversity and Biotechnology, State Key Laboratory of Microbial Technology, College of Life Sciences, Nanjing Normal University, Nanjing, PR China.
Xiangying XiangDepartment of High Altitude Medicine, Center for High Altitude Medicine, College of Life Sciences, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.
Yongjie HuangJiangsu Key Laboratory for Biodiversity and Biotechnology, State Key Laboratory of Microbial Technology, College of Life Sciences, Nanjing Normal University, Nanjing, PR China.
Qingqing WangJiangsu Key Laboratory for Biodiversity and Biotechnology, State Key Laboratory of Microbial Technology, College of Life Sciences, Nanjing Normal University, Nanjing, PR China.
Qiujinman MaoJiangsu Key Laboratory for Biodiversity and Biotechnology, State Key Laboratory of Microbial Technology, College of Life Sciences, Nanjing Normal University, Nanjing, PR China.
Xiaofei YanJiangsu Key Laboratory for Biodiversity and Biotechnology, State Key Laboratory of Microbial Technology, College of Life Sciences, Nanjing Normal University, Nanjing, PR China.
Ao DaiJiangsu Key Laboratory for Biodiversity and Biotechnology, State Key Laboratory of Microbial Technology, College of Life Sciences, Nanjing Normal University, Nanjing, PR China.
Najeeb UllahJiangsu Key Laboratory for Biodiversity and Biotechnology, State Key Laboratory of Microbial Technology, College of Life Sciences, Nanjing Normal University, Nanjing, PR China.
Hong LiJiangsu Key Laboratory for Biodiversity and Biotechnology, State Key Laboratory of Microbial Technology, College of Life Sciences, Nanjing Normal University, Nanjing, PR China.
Yin QiChengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan 610299, China.ORCID 0000-0003-0973-2307
Yanfu QuJiangsu Key Laboratory for Biodiversity and Biotechnology, State Key Laboratory of Microbial Technology, College of Life Sciences, Nanjing Normal University, Nanjing, PR China.
Xiang JiZhejiang Provincial Key Laboratory for Water Environment and Marine Biological Resources Protection, College of Life and Environmental Sciences, Wenzhou University, Wenzhou 325035, China.
Juergen BrosiusDepartment of High Altitude Medicine, Center for High Altitude Medicine, College of Life Sciences, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.ORCID 0000-0003-1650-2059
Cheng DengDepartment of High Altitude Medicine, Center for High Altitude Medicine, College of Life Sciences, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.ORCID 0000-0002-5296-8879

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endotherms use complex internal mechanisms to maintain a steady body temperature, whereas ectotherms rely on environmental factors and behaviors for thermoregulation. Certain ectothermic animals, like some lizards, can also physiologically regulate their body temperature to some extent, with interspecies variations in thermoregulatory capacity under low-temperature conditions. However, the molecular mechanisms underlying this physiological regulation have remained unclear since its discovery about 80 years ago. Here, we reveal that the hepatic expression of constitutively active glucagon receptor (GCGR) in lizards, particularly in iguana, correlated with their thermoregulatory capacity when kept at low temperatures. When

Indexed as

Body TemperatureBody Temperature RegulationLizardsReceptors, GlucagonAnimalsEnergy MetabolismGene Expression RegulationLiverMiceReceptors, Glucagon

Identifiers

PMID42627920
PMCPMC13496201

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.