Evidence map›Paper›PMID 42627899›Full record

ArticleScience advances2026

Metabolic-epigenetic rewiring of CCR5

Lingqi Xu, Wenyan Hao, Yingyi Yang, Yu Wang, Yaoshuang Li, Yuan Gong, Yifang Ding, Jie Huang, Zhenjiang Bai, Qiang Shan and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Lingqi XuInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.ORCID 0000-0002-4449-3711
Wenyan HaoInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.ORCID 0000-0002-1316-7294
Yingyi YangInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.ORCID 0009-0001-2864-7442
Yu WangInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
Yaoshuang LiInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
Yuan GongInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.ORCID 0009-0001-4530-7888
Yifang DingInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
Jie HuangInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.ORCID 0000-0002-4247-463X
Zhenjiang BaiInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.ORCID 0000-0002-9404-7058
Qiang ShanNational Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Suzhou, Jiangsu, China.ORCID 0000-0002-7089-0278
Rui KangDepartment of Surgery, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-2725-1574
Jiang Huai WangDepartment of Academic Surgery, University College Cork, Cork University Hospital, Cork, Ireland.
Haichao WangLaboratory of Emergency Medicine, the Feinstein Institutes for Medical Research, Manhasset, NY 11030, USA.ORCID 0000-0002-0211-9000
Timothy R BilliarDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA 15219, USA.ORCID 0000-0002-2949-0811
Jian WangInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.ORCID 0000-0003-2935-4964
Daolin TangDepartment of Surgery, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-1903-6180
Huiting ZhouInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.ORCID 0000-0003-1218-5391

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trained immunity enhances innate host defense by endowing monocytes with memory-like properties, yet the underlying integrated metabolic and epigenetic mechanisms remain elusive. Here, we demonstrate that coimmunization with Bacille Calmette-Guérin (BCG) and bacterial lipoprotein (BLP) induces a durable form of trained immunity that provides robust, long-term protection against polymicrobial sepsis from early life into adulthood. Single-cell RNA sequencing revealed that this effect is mediated by an expansion of CCR5

Indexed as

Epigenesis, GeneticMonocytesReceptors, CCR5SepsisTrained ImmunityAnimalsBCG VaccineHistonesHumansImmunity, InnateLipoproteinsMetabolic ReprogrammingMiceBCG VaccineCCR5 protein, humanHistonesLipoproteinsReceptors, CCR5

Identifiers

PMID42627899
PMCPMC13496178

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.