Evidence map›Paper›PMID 42627895›Full record

ArticleScience advances2026

δ2-Protocadherins organize parallel indirect basal ganglia circuits.

Naosuke Hoshina, Joshua M Boeckers, Erin M Johnson-Venkatesh, Miyuki Hoshina, Kana Matsumoto, Abhijnana Das, Veronica R Rally, Jaanvi Sant, Akiko Terauchi, Shinji Kinoshita and 2 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Naosuke HoshinaDepartment of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-2575-1356
Joshua M BoeckersDepartment of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-3314-4743
Erin M Johnson-VenkateshDepartment of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-2590-0737
Miyuki HoshinaDepartment of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Kana MatsumotoDepartment of Life Science and Medical Bioscience, Faculty of Science and Engineering, Waseda University, Tokyo 162-8480, Japan.
Abhijnana DasDepartment of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0009-0005-2886-741X
Veronica R RallyDepartment of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-3752-0176
Jaanvi SantDepartment of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Akiko TerauchiDepartment of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0009-0008-1244-3569
Shinji KinoshitaDepartment of Life Science and Medical Bioscience, Faculty of Science and Engineering, Waseda University, Tokyo 162-8480, Japan.ORCID 0009-0004-0438-6868
Takafumi InoueDepartment of Life Science and Medical Bioscience, Faculty of Science and Engineering, Waseda University, Tokyo 162-8480, Japan.ORCID 0000-0002-2728-0060
Hisashi UmemoriDepartment of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-7198-2062

Funding

Molecular Codes for the Establishment of Functionally Segregated Dopaminergic CircuitsR01MH125162 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI UMEMORI, HISASHI, WATABE-UCHIDA, MITSUKO · 2021 to 2025
$4.1M
Finding the projection-specific dopaminergic synaptic organizersR01DA042744 · NIDA · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori, Mitsuko Watabe-Uchida · 2017 to 2026
$3.9M
NIDA NIH HHS R01 DA042744NIMH NIH HHS R01 MH125162
6 · The paper itself

Abstract

The basal ganglia (BG) contain multiple parallel neural circuits, each of which may control different behaviors. However, how the distinct parallel BG circuits are molecularly organized is not known. Here, we show that two δ2-protocadherins (PCDHs), PCDH17 and PCDH10, which are homophilic cell adhesion molecules, establish and define two distinct indirect BG circuits that regulate different behaviors. PCDH17 and PCDH10 are expressed in a complementary expression pattern in the BG, anatomically defining two parallel indirect BG connections. Indirect pathway-specific

Indexed as

Basal GangliaCadherinsAnimalsMiceMice, KnockoutProtocadherinsCadherinsProtocadherins

Identifiers

PMID42627895
PMCPMC13496169

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.