ArticleScience advances2026
High-spatiotemporal resolution deuterium metabolic imaging enables in vivo phenotyping of intra- and intertumoral heterogeneity.
Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Intra- and intertumoral heterogeneities raise fundamental biological questions and have important implications for accurate cancer diagnosis, prognosis, and treatment. These heterogeneities reflect tumor complexity, including a pronounced diversity in metabolic phenotypes and profiles. This study demonstrates that in vivo deuterium metabolic imaging (DMI) data acquired with sufficiently high spatiotemporal resolution provide a minimally invasive approach to assess these heterogeneities. A multifrequency DMI approach was used to examine tumor heterogeneities within and between colon cancer models. Regions of high and low glucose enrichment and labeled lactate accumulation could thus be detected; these were analyzed using unsupervised clustering strategies based on
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