ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
RNA Promotes Synapsin Condensates That Organize Synaptic Vesicles in Live Neurons and Enable Localized Translation in Reconstituted System.
Branislava Rankovic, Zachary M Geisterfer, Akshita Chhabra, Vladimir M Jovanovic, Ian Seim, Christian Hoffmann, Antonela Condric, Gerard Aguilar Pérez, Rinse de Boer, Lars T Hofstede and 12 more
Abstract read
In one paragraphArticle in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
22 authors.
Antonela CondricInstitute of Biochemistry, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health & Laboratory of Molecular Neuroscience, German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.ORCID https://orcid.org/0009-0006-5898-848X Jingao SunInstitute of Biochemistry, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health & Laboratory of Molecular Neuroscience, German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.ORCID https://orcid.org/0009-0004-5395-1499 Kiara FreitagDepartment of Neuropathology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin and Berlin Institute of Health & German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.ORCID https://orcid.org/0000-0002-5244-3140 Marina JendrachDepartment of Neuropathology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin and Berlin Institute of Health & German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.ORCID https://orcid.org/0000-0002-8601-2277 Frank L HeppnerDepartment of Neuropathology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin and Berlin Institute of Health & German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.ORCID https://orcid.org/0000-0001-9816-8917 Vladimir DespicGoethe University Frankfurt, Institute For Molecular Biosciences, Frankfurt am Main, Germany.
Amy S GladfelterInstitute of Biochemistry, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health & Laboratory of Molecular Neuroscience, German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.ORCID https://orcid.org/0000-0002-2490-6945 Funding
Cytoplasmic Organization by phase transitionsR01GM081506 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GLADFELTER, AMY S · 2010 to 2023
$4.0MOrganization of Syncytial CellsR35GM156800 · NIGMS · DUKE UNIVERSITY · PI Amy S Gladfelter · 2025 to 2026
$1.1MThe role of biomolecular condensates in regulating the cytoskeleton.F32GM151858 · NIGMS · DUKE UNIVERSITY · PI GEISTERFER, ZACH · 2023 to 2025
$145kAir Force Office of Scientific Research FA9550-20-1-0241DFG Grant MI 2104DFG Grant SFB1286/B10ERC Grant MemLessInterface 101078172German Research Foundation MI2104German Research Foundation SFB1286/B10HFSP Grant RGEC32/2023Horizons Europe MSCA DN 101167843NIGMS NIH HHS 1R35GM156800NIGMS NIH HHS 7R01GM081506-13NIGMS NIH HHS F32 GM151858NIGMS NIH HHS F32 GM151858-02NIGMS NIH HHS R01 GM081506NIGMS NIH HHS R35 GM156800NIH ASG
6 · The paper itselfAbstract
Condensates at synapses organize synaptic vesicle (SV) clusters and are essential for efficient neurotransmitter release. While it is established that RNA granules traffic along axons, the function of RNA at the presynapse remains unclear. Here, we uncover a direct structural role of coding RNAs in organizing presynaptic condensates by focusing on SV clusters, condensates between synapsin-1 and lipid vesicles. Using in vitro reconstitution systems, we show that RNA drives synapsin-1 coacervation, with structured RNAs being more effective at promoting phase transitions. The importance of RNA was confirmed in living synapses, where acute disruption of native RNA induces a dispersion of SVs and synapsin. Conversely, ectopically expressed SV-like condensates contained the translational machinery. The microscopy-based in vitro translation assay demonstrates increased translation efficiency within synapsin-1/RNA condensates. Together, our work indicates a novel structural role of RNAs in modulating SV condensates.
Indexed as
localized translationneuronsphase separationRNA granulessynapsinsynaptic biologysynaptic vesicle
Identifiers
PMID42627687
PMCPMC13496291
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