Photodynamic therapy mediated by a selective nanoemulsion for breast cancer treatment: in vitro and in vivo evaluation.

Cristiano Ceron Jayme, Daniela Silvestrini Fernandes, Flávia S Matsuo, Nayara Rezende, Leonardo Barcelos de Paula, Antonio Claudio Tedesco

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Article in Discover nano, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Cristiano Ceron JaymeDepartment of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, Center of Nanotechnology and Tissue Engineering-Photobiology and Photomedicine Research Group, University of São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14.040-901, Brazil.

Daniela Silvestrini FernandesDepartment of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, Center of Nanotechnology and Tissue Engineering-Photobiology and Photomedicine Research Group, University of São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14.040-901, Brazil.

Flávia S MatsuoDepartment of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, Center of Nanotechnology and Tissue Engineering-Photobiology and Photomedicine Research Group, University of São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14.040-901, Brazil.

Nayara RezendeDepartment of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, Center of Nanotechnology and Tissue Engineering-Photobiology and Photomedicine Research Group, University of São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14.040-901, Brazil.

Leonardo Barcelos de PaulaDepartment of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, Center of Nanotechnology and Tissue Engineering-Photobiology and Photomedicine Research Group, University of São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14.040-901, Brazil.

Antonio Claudio TedescoDepartment of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, Center of Nanotechnology and Tissue Engineering-Photobiology and Photomedicine Research Group, University of São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14.040-901, Brazil. atedesco@usp.br.ORCID https://orcid.org/0000-0003-4198-9321

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we investigated the tumor-accumulating efficacy of photodynamic therapy (PDT) mediated by an aluminum chloride phthalocyanine-loaded nanoemulsion (AlClPc-NE) against breast cancer (MCF-7 and MDA-MB-231) and non-tumorigenic (MCF-10A) cell lines. The optimized AlClPc-NE formulation exhibited a mean hydrodynamic diameter of 168 nm, zeta potential of - 29 mV, low polydispersity (0.25), encapsulation efficiency of 81.10%, and estimated stability of 12 months. The system effectively preserved the drug photoactivity, achieving a robust singlet oxygen quantum yield (ΦΔ = 0.52). In vitro assays confirmed excellent dark biocompatibility of the nanocomposites. Upon irradiation, AlClPc-PDT exhibited potent phototoxicity. Crucially, a selective therapeutic window was observed 24 h post-treatment at a light density of 1000 mJ/cm

Indexed as

Breast cancerNanoemulsionPhotodynamic therapyPhthalocyanine

Identifiers

PMID42627597

DOI10.1186/s11671-026-04863-5

PMCPMC13498531

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.