ArticleMolecular biology reports2026
VDR BsmI polymorphism and obesity in vitamin D deficiency among undergraduate students: a cross-sectional study.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundUndergraduate students constitute a relevant population for investigating genetic and body weight-related factors associated with vitamin D deficiency. This study aimed to assess the associations of the VDR BsmI single nucleotide polymorphism (SNP) and body weight status, including obesity, with vitamin D deficiency in undergraduate students. METHODS AND
resultsThis cross-sectional study included biochemical and genetic assessment conducted between April and May 2023. A total of 189 students were evaluated after excluding individuals who had received vitamin D supplementation within the six months preceding data collection. SNP genotyping was performed by qPCR using TaqMan probes, vitamin D levels were measured by chemiluminescent immunoassay, and body weight classification was determined according to World Health Organization (WHO) criteria. Vitamin D deficiency was observed in 34.9% of the participants. Individuals with vitamin D deficiency had significantly higher body weight, waist and hip circumference, and body fat percentage than those with sufficient vitamin D levels. The distributions of the BsmI genotypes and alleles differed significantly between the vitamin D groups. Multivariate logistic regression showed that obesity (OR = 4.260; 95% CI: 1.656-10.959) and the recessive genetic model (OR = 4.361; 95% CI: 1.200-15.846) were independently associated with vitamin D deficiency.
conclusionsObesity and the VDR BsmI recessive genetic model were independently associated with higher odds of vitamin D deficiency in undergraduate students. These findings highlight the concurrent relevance of genetic and body weight-related factors to vitamin D status and support further research to inform preventive strategies in this population.
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