Evidence map›Paper›PMID 42627503›Full record

ArticleSurgery today2026

Long-term outcomes after salvage surgery for isolated lateral lymph node recurrence in rectal cancer.

Treerat Tangpulphon, Akira Ouchi, Nattapanee Sukphol, Tanyawan Heingraj, Kitrawee Jirathaniruangkit, Takashi Kinoshita, Yusuke Sato, Takayoshi Kishida, Songphol Malakorn, Koji Komori and 1 more

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Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Treerat TangpulphonDepartment of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
Akira OuchiDepartment of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan. akira.ouc@aichi-cc.jp.ORCID http://orcid.org/0000-0003-0435-5370
Nattapanee SukpholDepartment of Surgery, Chulabhorn Hospital, Princess Srisavangavadhana College of Medicine, Chulabhorn Royal Academy, Bangkok, Thailand.
Tanyawan HeingrajDepartment of Surgery, Khonkaen Hospital, Khonkaen, Thailand.
Kitrawee JirathaniruangkitCenter of Excellence in Colorectal Disease, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Takashi KinoshitaDepartment of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
Yusuke SatoDepartment of Surgery, Nagoya University Hospital, Nagoya, Japan.
Takayoshi KishidaDepartment of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
Songphol MalakornCenter of Excellence in Colorectal Disease, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Koji KomoriDepartment of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
Tetsuya AbeDepartment of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the oncologic outcomes and prognostic factors after salvage lateral lymph node resection for isolated lateral lymph node recurrence (LLNR).

methodsRectal cancer patients with isolated LLNR who underwent salvage surgery at tertiary centers in Japan and Thailand between January 2013 and December 2024 were included. The primary endpoints were overall survival (OS), recurrence-free survival (RFS), and local re-recurrence.

resultsThirty patients were included, with a median follow-up of 47.5 months. Salvage procedures included tumor resection in 19 patients (63.3%), tumor resection with adjacent organ resection in 5 (16.7%), and total pelvic exenteration in 6 (20.0%). After salvage surgery, 21 patients (70.0%) developed re-recurrence, and 11 (36.7%) had local re-recurrence. The five-year OS was 73.8%, 5-year RFS was 22.3%, and 5-year cumulative incidence of local re-recurrence was 61.7%. A multivariate analysis revealed that extensive salvage operations, including tumor resection with adjacent organ resection and total pelvic exenteration, were strongly associated with local re-recurrence (HR 8.43, p = 0.014). An LLN size ≥ 17 mm tended to increase the risk of local re-recurrence (HR 3.52, p = 0.071).

conclusionSalvage resection for isolated LLNR provides an acceptable OS, but re-recurrence remains frequent. Careful patient selection using PET-CT and multidisciplinary discussions are essential, particularly for patients who require extensive surgery.

Indexed as

and Local re-recurrenceLateral lymph node recurrenceOverall survivalRecurrence-free survivalSalvage surgery

Identifiers

PMID42627503

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