Evidence map›Paper›PMID 42627479›Full record

ArticleApplied biochemistry and biotechnology2026

Integrative Systems Pharmacology and Zebrafish Toxicity Profiling Reveal Piperine as a Multi-Target Modulator in DSS-Induced Intestinal Inflammation.

Kumar Pavithra, Kasthuri Kannayiram, Mathava Prakash Ramamoorthi, Rajan Radha Rasmi, Cecileya Jasmin Meshak Dhanasekaran, Kunnathur Murugesan Sakthivel

Abstract read
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Article in Applied biochemistry and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kumar PavithraDepartment of Biochemistry, PSG College of Arts & Science, Civil Aerodrome Post, Coimbatore, Tamil Nadu, 641014, India.
Kasthuri KannayiramDepartment of Biochemistry, Meenakshi Medical College Hospital and Research Institute, Meenakshi Academy of Higher Education and Research Institute, Kanchipuram, Tamil Nadu, 631552, India.
Mathava Prakash RamamoorthiDepartment of Biochemistry, PSG College of Arts & Science, Civil Aerodrome Post, Coimbatore, Tamil Nadu, 641014, India.
Rajan Radha RasmiDepartment of Biotechnology, PSG College of Arts & Science, Civil Aerodrome Post, Coimbatore, Tamil Nadu, 641014, India.
Cecileya Jasmin Meshak DhanasekaranDepartment of Biochemistry, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, 602105, India.
Kunnathur Murugesan SakthivelDepartment of Biochemistry, PSG College of Arts & Science, Civil Aerodrome Post, Coimbatore, Tamil Nadu, 641014, India. sakthikm@gmail.com.ORCID http://orcid.org/0000-0002-9828-5643

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A bioactive alkaloid derived from Piper nigrum is piperine (PIP); it exhibits significant anti-inflammatory properties, but the mechanistic basis remains incomplete. This study integrates zebrafish toxicity assays, antioxidant profiling and histopathology analysis along with a network pharmacology approach to elucidate system-level understanding of PIP's therapeutic efficacy. Toxicity studies on zebrafish embryos indicated that PIP exhibits low toxicity at elevated dosages (LC

Indexed as

InflammationMolecular dockingNetwork pharmacologyPiperineToxicity assays

Identifiers

PMID42627479

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.