ArticleObesity surgery2026
Five-Year Endoscopic Outcomes After One-Anastomosis Gastric Bypass: A Multicenter Cohort with Bile Reflux, Marginal Ulcers, and Symptom Correlation.
Article in Obesity surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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15 authors.
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Abstract
backgroundOne-anastomosis gastric bypass (OAGB) is increasingly adopted worldwide as a primary bariatric procedure. Concerns persist regarding long-term gastroesophageal reflux disease (GERD), bile reflux, and postoperative mucosal injury. We evaluated 5-year endoscopic and histological outcomes after OAGB and their correlation with symptoms and preoperative risk factors.
methodsWe analyzed 1,172 patients undergoing OAGB at four high-volume bariatric centers between July 2015 and February 2020. Patients with major perioperative complications, reoperations, or incomplete follow-up were excluded. Clinical assessment included the GERD-Health-Related Quality-of-Life (GERD-HRQL) questionnaire and a modified Gastrointestinal Symptom Rating Scale (GSRS) focusing on abdominal pain. Upper endoscopy (UE) with systematic biopsy of the gastric pouch was performed according to a standardized protocol.
resultsMean follow-up was 62 ± 26 months (range 60-84). Mean BMI decreased from 44.31 ± 6.28 kg/m
conclusionsAt 5 years, OAGB provides durable weight loss with low rates of erosive esophagitis. However, gastric pouch gastritis and anastomotic ulcers remain clinically relevant, particularly in patients with modifiable risk factors; targeted endoscopic surveillance and risk-factor management may reduce long-term mucosal injury.
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