Distinct Transcriptional States of TDP-43 Pathology in an Alzheimer's Disease Mouse Model.

Ji-Chuan Liu, Wen-Jin Liu, Li-Qiang Yu, Jie Li, Yan-Yun Sun, Shao Li, Quan-Hong Ma

Abstract read

In one paragraph

Article in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ji-Chuan LiuLiaoning Provincial Key Laboratory of Cerebral Diseases, Department of Physiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, 116044, China.ORCID http://orcid.org/0009-0004-8346-6670

Wen-Jin LiuJiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, 215123, China.

Li-Qiang YuDepartment of General Practice, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, 215004, China.

Jie LiDepartment of General Practice, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, 215004, China.

Yan-Yun SunJiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, 215123, China.ORCID https://orcid.org/0000-0001-5092-7590

Shao LiLiaoning Provincial Key Laboratory of Cerebral Diseases, Department of Physiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, 116044, China. lishao89@dmu.edu.cn.ORCID http://orcid.org/0000-0001-5437-6554

Quan-Hong MaJiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, 215123, China. maquanhong@suda.edu.cn.ORCID http://orcid.org/0000-0001-9392-8956

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is frequently accompanied by cytoplasmic TDP-43 inclusions, although its pathogenic role remains unclear. Using Immuno-LCM-RNAseq in hippocampal excitatory neurons from APP/PS1 mice, we characterized two distinct TDP-43 states: diffuse cytoplasmic mislocalization (Cyto

Indexed as

Alzheimer’s diseaseNeurodegenerationNeurodegenerative diseaseNeuronProtein aggregationTARDBPTDP-43

Identifiers

PMID42627473

DOI10.1016/j.mcn.2019.103396

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.