A versatile viscosity-responsive aggregation-induced emission fluorescent probe for bioimaging, fingerprint visualization and food quality monitoring.

Wanshuo Luo, Fuyan Tang, Wu Du, Anyang Wang, Chuanchen Wu, Qinggang Zhang, Haibin Xiao

Abstract read

In one paragraph

Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Wanshuo LuoSchool of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, 255000, P. R. China.

Fuyan TangSchool of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, 255000, P. R. China.

Wu DuDrug Dispensing Department, Zibo Central Hospital, Zibo, 255020, P. R. China.

Anyang WangSchool of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, 255000, P. R. China.

Chuanchen WuSchool of Medicine, Linyi University, Linyi, 276000, P. R. China. wuchuanchen@lyu.edu.cn.

Qinggang ZhangSchool of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, 255000, P. R. China. zhangqg@sdut.edu.cn.

Haibin XiaoSchool of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, 255000, P. R. China. haibinxiao@sdut.edu.cn.

Funding

National Natural Science Foundation of China 21907058National Natural Science Foundation of China 22205136Young Taishan Scholars Program of Shandong Province tsqn202306196Youth Fund of Natural Science Foundation of Shandong Province ZR2025QC107

6 · The paper itself

Abstract

Microenvironmental viscosity constitutes a critical physical parameter that modulates biological behaviors, material performances and chemical reaction processes. Accordingly, developing fluorescent probes capable of sensitive and visual detection of microenvironmental viscosity is of great significance. This study designed and synthesized a novel viscosity-responsive fluorescent probe (TPA-Q) based on triphenylamine and hydroxyethyl quinolinium iodide. The probe exhibits weak fluorescence in low-viscosity solvents, but in high-viscosity environments or aggregated states, its intramolecular motion is restricted, leading to significant fluorescence enhancement and thus demonstrating excellent aggregation-induced emission (AIE) properties and viscosity sensitivity. Utilizing this unique characteristic, we successfully utilized this single probe for multi-scenario applications. For food science field, TPA-Q could evaluate the thickening effects of various thickening agents and distinguish the viscosity differences of the actual samples. Moreover, the probe can be used for fingerprint imaging through the method of solution immersion with low concentration. Furthermore, bioimaging experiments verified that TPA-Q could target mitochondria and monitor the viscosity fluctuations under various stimuli. As an AIE probe, TPA-Q displays strong flexibility and practical value of for bioimaging, fingerprint visualization and food quality monitoring.

Indexed as

Fluorescent DyesAnimalsFluorescent Chemosensor CompoundsHumansOptical ImagingQuinolinium CompoundsSpectrometry, FluorescenceViscosityFluorescent Chemosensor CompoundsFluorescent DyesQuinolinium CompoundsAIEBioimagingFingerprint developmentFluorescent probeFood monitoringViscosity detection

Identifiers

PMID42627420

DOI10.1007/s00604-026-08356-1

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.