Evidence map›Paper›PMID 42627407›Full record

ArticleJournal of virology2026

Trophoblast metabolic reprogramming triggers adverse pregnancy outcomes during DENV-2 infection in mice.

Han Wang, Fei-Yang Xue, Shi-Qi He, Jin-Fan Yang, Hao Zhang, Jia-Ying Cao, Jia-Tong Chang, Chen Zhang, Jing An, Zi-Yang Sheng and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Han WangDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.ORCID 0009-0003-5064-5616
Fei-Yang XueDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Shi-Qi HeDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Jin-Fan YangDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Hao ZhangDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Jia-Ying CaoDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Jia-Tong ChangDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Chen ZhangDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Jing AnDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.ORCID 0000-0002-2567-0380
Zi-Yang ShengDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.ORCID 0000-0001-7370-9465
Pei-Gang WangDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.ORCID 0000-0001-6045-2007

Funding

National Natural Science Foundation of China 32370163
6 · The paper itself

Abstract

Adverse pregnancy outcomes associated with dengue virus (DENV) infection are a severe manifestation of dengue fever; however, we still poorly understand the underlying mechanisms. Trophoblast dysfunction in the placenta contributes centrally to various pregnancy complications. As the functional unit of the placenta, the syncytiotrophoblast (STB) requires continuous fusion of precursor trophoblasts and adequate energy supply. In this study, we established a model of adverse pregnancy by infecting

Indexed as

DengueDengue VirusPregnancy Complications, InfectiousTrophoblastsAnimalsDisease Models, AnimalFemaleGlycolysisHypoxia-Inducible Factor 1, alpha SubunitMetabolic ReprogrammingMiceMice, KnockoutOxidative PhosphorylationOxidative StressPlacentaPregnancyHypoxia-Inducible Factor 1, alpha SubunitReceptor, Interferon alpha-betaadverse pregnancy outcomedengue virusmetabolic reprogramsyncytialization

Identifiers

PMID42627407
PMCPMC13595951

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.