ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Macrophage PABPC4-SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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15 authors.
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Abstract
Poly(A)-binding proteins (PABPs) are frequently dysregulated in cancers, yet their functional roles remain largely elusive. Here, we identify that PABPC4, a member of PABPs, is upregulated during colorectal cancer (CRC) progression and associated with poor prognosis. Single-cell transcriptomics reveals that PABPC4 is predominantly expressed in the macrophages of the tumor microenvironment (TME). Conditional knockout of Pabpc4 in macrophages (C4cKO) profoundly inhibited the progression of multiple cancers, including CRC, melanoma, and ovarian cancer. Mechanistically, C4cKO obviously enhances the local and systemic antitumor immunity, characterized by increased M1-like macrophages and cytotoxic CD8
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