ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
One-Step Immobilized Phage Depolymerase Coatings for Catheter-Related Bloodstream Infections.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Catheter-related bloodstream infection (CRBSI) is an important clinical problem that causes significant mortality and excess economic cost. Recent epidemiological trends indicate a shift in CRBSI pathogens from Gram-positive to Gram-negative bacilli, among which Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter baumannii predominate due to their strong antibiotic resistance and biofilm-forming capabilities. Recently, bacteriophage-encoded depolymerases have emerged as promising antivirulence agents that resensitize bacteria to host immunity by degrading capsular polysaccharides (CPS) and exopolysaccharides (EPS). In this study, we employed a mussel-inspired polydopamine (PDA) coating technique to immobilize an A. baumannii-specific depolymerase, DPO71, onto diverse organic, inorganic, and metal substrates, with a maximum surface coverage of ∼0.2 µg/cm
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