Evidence map›Paper›PMID 42627216›Full record

ArticleApplied and environmental microbiology2026

Characterization of vaginal lactobacilli from South African women toward the development of a biotherapeutic to optimize the vaginal microbiome.

Jenna Wilson, Aleya Sarah Amir Hamzah, Christine Jordan, Joshua A Hayward, Brian R Kullin, Monalisa T Manhanzva, David Tyssen, Celia Mehou-Loko, Andrea G Abrahams, Nina Radzey and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied and environmental microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Jenna Wilson *Life Sciences Discipline, Women's, Children's and Adolescents' Health and Disease Elimination Programs, Burnet Institute, Melbourne, Victoria, Australia.ORCID 0009-0009-0232-6905
Aleya Sarah Amir Hamzah *Life Sciences Discipline, Women's, Children's and Adolescents' Health and Disease Elimination Programs, Burnet Institute, Melbourne, Victoria, Australia.ORCID 0009-0004-1357-4748
Christine JordanLife Sciences Discipline, Women's, Children's and Adolescents' Health and Disease Elimination Programs, Burnet Institute, Melbourne, Victoria, Australia.
Joshua A HaywardLife Sciences Discipline, Women's, Children's and Adolescents' Health and Disease Elimination Programs, Burnet Institute, Melbourne, Victoria, Australia.ORCID 0000-0003-3904-3051
Brian R KullinDepartment of Pathology, University of Cape Town, Cape Town, South Africa.
Monalisa T ManhanzvaDepartment of Pathology, University of Cape Town, Cape Town, South Africa.
David TyssenLife Sciences Discipline, Women's, Children's and Adolescents' Health and Disease Elimination Programs, Burnet Institute, Melbourne, Victoria, Australia.
Celia Mehou-LokoDepartment of Pathology, University of Cape Town, Cape Town, South Africa.
Andrea G AbrahamsDepartment of Pathology, University of Cape Town, Cape Town, South Africa.
Nina RadzeyLife Sciences Discipline, Women's, Children's and Adolescents' Health and Disease Elimination Programs, Burnet Institute, Melbourne, Victoria, Australia.
Rushil HarryparsadDepartment of Pathology, University of Cape Town, Cape Town, South Africa.
Bahiah MeyerDepartment of Pathology, University of Cape Town, Cape Town, South Africa.
Anna C HearpsLife Sciences Discipline, Women's, Children's and Adolescents' Health and Disease Elimination Programs, Burnet Institute, Melbourne, Victoria, Australia.
Mark ZiemannLife Sciences Discipline, Women's, Children's and Adolescents' Health and Disease Elimination Programs, Burnet Institute, Melbourne, Victoria, Australia.
Hilton HumphriesCentre for Community-Based Research, Human Science Research Council, Pietermaritzburg, South Africa.
Pamela MkhizeBiochemistry Department, School of Life Sciences, University of KwaZulu-Natal, Pietermaritzburg, South Africa.
Linda-Gail BekkerDesmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-0755-4386
Jo-Ann S PassmoreDepartment of Pathology, University of Cape Town, Cape Town, South Africa.
Heather B JaspanDepartment of Pathology, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-0745-6073
Anna E SheppardSchool of Biological Sciences, The University of Adelaide, Adelaide, Australia.ORCID 0000-0002-2913-0920
Gilda TachedjianLife Sciences Discipline, Women's, Children's and Adolescents' Health and Disease Elimination Programs, Burnet Institute, Melbourne, Victoria, Australia.
Lindi MassonLife Sciences Discipline, Women's, Children's and Adolescents' Health and Disease Elimination Programs, Burnet Institute, Melbourne, Victoria, Australia.ORCID 0000-0002-2539-817X

Funding

Mucosal injury from sexual practices: Behaviour and biology of South African adolescentsR01AI128792 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI JASPAN, HEATHER BERYL, PASSMORE, JO-ANN SHELLEY · 2017 to 2020
$2.2M
Australian Centre for HIV and Hepatitis Virology ResearchAustralian National Health and Medical Research Council APP1195837Carnegie Corporation of New York Development of Emerging Academic Leaders in AfricaJoe White BequestNational Research Foundation of South Africa RCA13101054658NIAID NIH HHS R01 AI128792NIH HHS 1R01AI128792
6 · The paper itself

Abstract

HIV remains among the world's most serious healthcare challenges, with adolescent girls and young women in sub-Saharan Africa at particularly high risk of infection. Bacterial vaginosis (BV) is a key risk factor for HIV acquisition; however, current treatment strategies are limited. Optimal vaginal lactobacilli protect against BV and HIV, largely through immunoregulatory and antimicrobial activities mediated in part by lactic acid. Toward the development of a live biotherapeutic for African women, we sampled 181 isolates of vaginal lactobacilli from 25 BV-negative South African women. Fifty isolates were selected for evaluation of inflammatory responses using vaginal epithelial cells, D- and L-lactate, lactic acid production, and culture acidification. Aside from a single

Indexed as

LactobacillusMicrobiotaVaginaVaginosis, BacterialAdolescentAdultBiological TherapyFemaleHIV InfectionsHumansLactic AcidSouth AfricaSouthern African PeopleYoung AdultLactic AcidHIVlactobacillilive biotherapeuticSouth Africavaginal microbiome

Identifiers

PMID42627216
PMCPMC13599504

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.