ArticleMicrobiology spectrum2026
Parameters affecting the reliable measurement of fluconazole tolerance using disk diffusion assays with
Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Disk diffusion assays (DDAs) are widely used to determine antimicrobial susceptibility, which is measured as the size of the zone of inhibition (ZOI) after 24 h of growth, and is inversely proportional to the minimal inhibitory concentration (MIC). DDAs can also be used to measure the level of antifungal drug tolerance, defined as the degree to which a subpopulation of cells grows slowly at drug concentrations above the MIC. Tolerance occurs via one or more mechanisms that involve stress responses and that are distinguishable from mechanisms of drug resistance. Measurements of antifungal drug tolerance are generally more sensitive to growth parameters, such as temperature and pH. Here, we investigated parameters used for executing DDAs and asked if they affect the reproducibility of fluconazole susceptibility and tolerance measurements using
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