Evidence map›Paper›PMID 42627154›Full record

ArticlemBio2026

Tunneling nanotubes contribute to Zika virus pathogenesis at the maternal-fetal interface

Rafael Tomoya Michita, Long B Tran, Joyce Jose, Indira U Mysorekar

Abstract read
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rafael Tomoya Michita *Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0003-3156-9382
Long B Tran *Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-5061-1120
Joyce JoseDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0003-1261-6921
Indira U MysorekarDepartment of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0003-3917-8677

Funding

Safety, Testing/Transmission, and Outcomes in Pregnancy with COVID-19 (STOP-COVID-19 study)R01HD091218 · NICHD · WASHINGTON UNIVERSITY · PI DIAMOND, MICHAEL S, MYSOREKAR, INDIRA U · 2017 to 2022
$4.1M
Mechanisms of tunneling nanotube formation by ZIKV NS1 in viral host interactions at the maternal-fetal interfaceR01AI176505 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI Joyce Jose, Indira U Mysorekar · 2024 to 2026
$2.3M
The Role of Tunneling Nanotubes and Mitochondrial programming in HIV-Associated Placental DysfunctionK99AI194972 · NIAID · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Rafael Tomoya Michita · 2025 to 2026
$318k
NIAID NIH HHS K99 AI194972NIAID NIH HHS R01 AI176505NICHD NIH HHS R01 HD091218
6 · The paper itself

Abstract

Zika virus (ZIKV) infection during pregnancy can result in severe fetal outcomes, yet the mechanisms of transplacental dissemination remain incompletely defined. We previously showed that ZIKV induces tunneling nanotubes (TNTs), actin-rich intercellular conduits that enable direct cell-to-cell transfer of viral components. Here, we investigated the

Indexed as

Infectious Disease Transmission, VerticalNanotubesPlacentaPregnancy Complications, InfectiousZika VirusZika Virus InfectionAnimalsDisease Models, AnimalFemaleHumansMicePregnancyViral Nonstructural ProteinsViral Nonstructural ProteinsIFN-λNS1placentaTNTZIKV

Identifiers

PMID42627154
PMCPMC13556233

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.