Evidence map›Paper›PMID 42627152›Full record

ArticlemSphere2026

Expansion and optimization of the auxin-inducible degron 2 (AID2) system in

Emily L Danzeisen, Michelle V Lihon, Kedric L Milholland, Taylor R Bias, Audrey F Bates, Mark C Hall

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Emily L Danzeisen *Department of Biochemistry, Purdue University, West Lafayette, Indiana, USA.ORCID 0009-0000-1739-1739
Michelle V Lihon *Department of Biochemistry, Purdue University, West Lafayette, Indiana, USA.
Kedric L MilhollandDepartment of Biochemistry, Purdue University, West Lafayette, Indiana, USA.
Taylor R BiasDepartment of Biochemistry, Purdue University, West Lafayette, Indiana, USA.
Audrey F BatesDepartment of Biochemistry, Purdue University, West Lafayette, Indiana, USA.
Mark C HallDepartment of Biochemistry, Purdue University, West Lafayette, Indiana, USA.ORCID 0000-0001-6429-2506

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI ANDREW D MESECAR · 1985 to 2026
$43.4M
Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Cdc14 phosphatase - novel roles in drug resistance, virulence, and the response to cell wall stress in fungal pathogensR01AI168050 · NIAID · PURDUE UNIVERSITY · PI Mark C Hall · 2023 to 2026
$2.4M
Development and application of auxin-inducible degradation in Candida pathogensR21AI174123 · NIAID · PURDUE UNIVERSITY · PI HALL, MARK C · 2023 to 2024
$423k
National Institute of Allergy and Infectious Diseases AI168050, AI174123NCATS NIH HHS UL1 TR002529NCI NIH HHS P30 CA023168NIAID NIH HHS R01 AI168050NIAID NIH HHS R21 AI174123
6 · The paper itself

Abstract

The auxin-inducible degron (AID) technology is a convenient and powerful tool for protein functional characterization in a broad array of eukaryotic species. We recently demonstrated that the original AID and improved AID2 systems are very effective at rapid protein depletion in IMPORTANCE: Invasive fungal infections, including those caused by

Indexed as

Candida albicansFungal ProteinsGene EditingIndoleacetic AcidsCRISPR-Cas SystemsDegronsGenetic VectorsFungal ProteinsIndoleacetic AcidsAID2auxin-inducible degradationauxin-inducible degronCandida albicansCandida aurisCandida glabrataCDC14GLC7HGC1inducible protein degradationPPH21targeted protein degradation

Identifiers

PMID42627152
PMCPMC13621846

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.