Evidence map›Paper›PMID 42627148›Full record

ArticleCatheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions2026

Clinical Outcomes of the Allegra Transcatheter System in Bioprosthetic Aortic Valve Failure: A Multicentre Valve-in-Valve Registry.

Hilal Khan, Mohamed Ali, Abdalazeem Ibrahem, Karim Ratib, Nur Ilia Mohd Zaki, Freidoon Keshavarzi, Alok Shah, Hesham Abdelaziz, Ayush Khurana, Alexander Chase and 5 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hilal KhanCardiothoracic Department, Freeman Hospital, Newcastle Upon Tyne, UK.ORCID https://orcid.org/0000-0003-0412-2227
Mohamed AliCardiothoracic Department, Freeman Hospital, Newcastle Upon Tyne, UK.
Abdalazeem IbrahemCardiothoracic Department, Freeman Hospital, Newcastle Upon Tyne, UK.ORCID https://orcid.org/0000-0003-2688-6295
Karim RatibKeele Cardiovascular Research Group, Centre for Prognosis Research, Institute for Primary Care and Health Sciences, Keele University, Keele, UK.ORCID https://orcid.org/0000-0002-4860-8213
Nur Ilia Mohd ZakiCardiac Department, Manchester Royal Infirmary, Manchester, UK.
Freidoon KeshavarziCardiac Department, Manchester Royal Infirmary, Manchester, UK.ORCID https://orcid.org/0009-0000-8670-6060
Alok ShahLancashire Cardiac Centre, Blackpool Victoria Hospital, Blackpool, UK.ORCID https://orcid.org/0000-0002-2138-5777
Hesham AbdelazizLancashire Cardiac Centre, Blackpool Victoria Hospital, Blackpool, UK.ORCID https://orcid.org/0000-0002-5165-9919
Ayush KhuranaSwansea Bay University Health Board, Swansea, UK.
Alexander ChaseSwansea Bay University Health Board, Swansea, UK.
Diana A GorogNational Heart and Lung Institute, Imperial College, London, UK.ORCID https://orcid.org/0000-0002-9286-1451
Rajiv DasCardiothoracic Department, Freeman Hospital, Newcastle Upon Tyne, UK.
Azfar ZamanCardiothoracic Department, Freeman Hospital, Newcastle Upon Tyne, UK.ORCID https://orcid.org/0000-0003-4891-8892
Mohammad AlKhalilCardiothoracic Department, Freeman Hospital, Newcastle Upon Tyne, UK.
Mohamed FaragCardiothoracic Department, Freeman Hospital, Newcastle Upon Tyne, UK.ORCID https://orcid.org/0000-0003-0811-7679

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe prevalence of bioprosthetic aortic valve failure is increasing due to the broader use of bioprosthetic valves, both surgical and transcatheter, and an ageing population. Registry data indicate a higher risk of coronary obstruction and elevated gradients following valve-in-valve transcatheter aortic valve implantation (TAVI). We report outcomes of the Allegra transcatheter heart valve system in valve-in-valve TAVI.

methodsIn this retrospective multicentre cohort study, all patients undergoing valve-in-valve TAVI with the Allegra system between 2019 and 2025 at five UK centers were included. The combined primary outcomes were technical success, device success, and early safety at 30 days, as per the VARC-3 (Valve Academic Research Consortium-3) criteria. A key secondary outcome was all-cause mortality at the longest documented follow-up.

resultsA total of 106 patients underwent valve-in-valve TAVI. The mean age was 79 ± 6 years, with 57.5% being female. Almost half of the patients had an index valve ≤ 21 mm, with an STS (Society of Thoracic Surgery) score of 7.1% (5.1-12.0). The post-implant aortic valve mean pressure gradient was 12 ± 6 mmHg, and the mean valve area was 1.7 ± 0.5 cm

conclusionsThe Allegra TAVI system demonstrates promising technical and device success rates, with early safety and good post-implant haemodynamic performance in high-risk patients undergoing valve-in-valve TAVI. Larger randomized trials are needed to confirm these results.

Indexed as

Aortic ValveAortic Valve StenosisBioprosthesisHeart Valve ProsthesisProsthesis FailureTranscatheter Aortic Valve ReplacementAgedAged, 80 and overFemaleHemodynamicsHumansMaleProsthesis DesignRegistriesRetrospective StudiesRisk AssessmentAllegraaortic stenosisTAVItranscatheter aortic valve implantationvalve‐in‐valve

Identifiers

PMID42627148
PMCPMC13667307

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.