ArticleThe Journal of international medical research2026
Successful rescue of a patient with extensive lethal-dose aluminum phosphide poisoning complicated by multiple organ dysfunction syndrome.
Article in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aluminum phosphide poisoning is a highly lethal toxicological emergency associated with an extremely high mortality rate, and no specific antidote is currently available. Aluminum phosphide rapidly releases phosphine gas after coming into contact with gastric acid, which strongly inhibits mitochondrial cytochrome c oxidase, leading to severe cellular metabolic disorder, lactic acidosis, refractory shock, and progressive multiple organ dysfunction syndrome. In severe cases, the mortality rate can approach 100%. We report the case of a man in his early 40s who intentionally ingested 25.2 g of aluminum phosphide, equivalent to approximately 16 times the human lethal dose (based on a lethal dose of 1.5 g). The patient rapidly developed fulminant multiple organ dysfunction syndrome, including refractory cardiogenic shock, acute respiratory distress syndrome, acute kidney injury, liver dysfunction, hypocalcemia, and secondary ventilator-associated pneumonia caused by
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