Evidence map›Paper›PMID 42627048›Full record

ArticleInternational journal of oncology2026

KIAA1429 knockdown alleviates osteosarcoma  progression by destabilizing SLC7A11 mRNA via m6A methylation to promote ferroptosis.

Hui Zeng, Yunyan Zhong, Dingbiao Zeng, Shiliang Xiao, Song Zou

Abstract read
In one paragraph

Article in International journal of oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hui ZengDepartment of Orthopedics, Ganzhou People's Hospital, Ganzhou, Jiangxi 341000, P.R. China.
Yunyan ZhongDepartment of Medical Records, Ganzhou People's Hospital, Ganzhou, Jiangxi 341000, P.R. China.
Dingbiao ZengDepartment of Orthopedics, Ganzhou People's Hospital, Ganzhou, Jiangxi 341000, P.R. China.
Shiliang XiaoDepartment of Orthopedics, Ganzhou People's Hospital, Ganzhou, Jiangxi 341000, P.R. China.
Song ZouDepartment of Interventional Radiology and Vascular Surgery, Ganzhou Key Laboratory of Interventional Medicine, Ganzhou Hospital-Nanfang Hospital, Southern Medical University (Ganzhou People's Hospital), Ganzhou, Jiangxi 341000, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteosarcoma (OS) is a highly aggressive bone tumor with limited therapeutic options. As a key component of the N6‑methyladenosine (m6A) methyltransferase complex, KIAA1429 contributes to tumor progression; however, its role in OS remains unclear. For the present study, four human OS cell lines (MG63, 143B, U2OS and Saos‑2) and an osteoblast cell line (hFOB1.19) were cultured

Indexed as

Amino Acid Transport System y+Bone NeoplasmsFerroptosisOsteosarcomaAdenosineAnimalsCell Line, TumorCell ProliferationDisease ProgressionFemaleGene Expression Regulation, NeoplasticGene Knockdown TechniquesHumansMiceMice, Inbred BALB CMice, NudeAdenosineAmino Acid Transport System y+N-methyladenosineRNA-Binding ProteinsRNA, MessengerSLC7A11 protein, humanVIRMA protein, humanferroptosisKIAA1429N6‑methyladenosine methylationosteosarcomasolute carrier family 7 member 11

Identifiers

PMID42627048
PMCPMC13553193

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.