Evidence map›Paper›PMID 42627043›Full record

ArticleChemistry & biodiversity2026

Design, Synthesis, and Biological Evaluation of Amide Derivatives of Coumarin-1,2,4-Thiadiazoles as Anticancer Agents.

Arun Kumar Lingala, Kiran Kumar Murahari, Laxminarayana Eppakayala, Ravinder Manchal

Abstract read
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Arun Kumar LingalaMedicinal Chemistry Division, Aragen Life Sciences Private Limited (Previously Known As GVK Biosciences Private Limited), Hyderabad, Telangana, India.ORCID https://orcid.org/0009-0000-5016-8934
Kiran Kumar MurahariMedicinal Chemistry Division, Aragen Life Sciences Private Limited (Previously Known As GVK Biosciences Private Limited), Hyderabad, Telangana, India.
Laxminarayana EppakayalaDepartment of Chemistry, School of Engineering, Anurag University, Hyderabad, Telangana, India.ORCID https://orcid.org/0000-0003-4465-042X
Ravinder ManchalDepartment of Chemistry, Chaitanya (Deemed to Be University), Warangal, Telangana, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new library of substituted amide derivatives of coumarin-1,2,4-thiadiazoles (12a-j) was synthesized, and their chemical structures were confirmed by spectroscopic techniques. The synthesized compounds were evaluated for their in vitro anticancer activity against a panel of human cancer cell lines, including PC3 (prostate), A549 (lung), MCF-7 (breast), and SiHa (cervix), using the MTT assay, with etoposide as the positive control. The compounds exhibited good to moderate anticancer activity, with IC

Indexed as

AmidesAntineoplastic AgentsCoumarinsDrug DesignThiadiazolesCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular StructureStructure-Activity RelationshipAmidesAntineoplastic AgentsCoumarinsThiadiazolesanticancer propertiescoumarin,1,2,4‐thiadiazoledendrodoineirosustat

Identifiers

PMID42627043
PMCPMC13495655

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.