ArticleChemistry & biodiversity2026
Evidence for the Induction of Anxiolytic-Like Behavior and Memory Preservation by (+)-Dihydrocarvone Through Studies in Adult Zebrafish and In Sílico.
Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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12 authors.
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Abstract
Anxiety and seizures are prevalent conditions worldwide, with conventional treatment relying on benzodiazepines. However, the long-term use of these drugs is associated with adverse effects and the development of dependence, driving the search for safer therapeutic alternatives. (+)-Dihydrocarvone is a monoterpene ketone with documented biological activities, including antifungal, antiparasitic, and anti-inflammatory effects. This study utilized adult zebrafish (*Danio rerio*), an animal model widely used in pharmacological and behavioral research due to its neurobiological similarity to mammals. Toxicity tests, assessments of anxiolytic activity and memory effects, and *in silico* studies were conducted. The results demonstrated anxiolytic-like effects and memory preservation associated with (+)-dihydrocarvone, with pharmacological data suggesting the possible involvement of GABAergic and serotonergic pathways. Furthermore, molecular interaction analyses revealed affinity for the GABA∼A receptor, indicating a potential pharmacological effect.
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