Evidence map›Paper›PMID 42627029›Full record

ArticleLab on a chip2026

Finger-actuated microfluidic device for point-of-care circulating cell-free nucleic acid extraction.

Ghulam Musaddaq, Labibah Ehsan, Yano Yoga, Joshua Castillo, Linda Marriott, Nicholas R Leslie, Deborah Williamson, Thomas Tran, Chuan Kok Lim, Maïwenn Kersaudy-Kerhoas

Abstract read
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In one paragraph

Article in Lab on a chip, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ghulam MusaddaqSchool of Engineering and Physical Sciences, Heriot-Watt University, UK. m.kersaudy-kerhoas@hw.ac.uk.ORCID http://orcid.org/0009-0002-5025-7958
Labibah EhsanMiddle East Technical University, Türkiye.ORCID http://orcid.org/0009-0008-1087-4728
Yano YogaVictorian Infectious Diseases Reference Laboratory at the Peter Doherty Institute for Infection and Immunity, Royal Melbourne Hospital, Australia.
Joshua CastilloSchool of Engineering and Physical Sciences, Heriot-Watt University, UK. m.kersaudy-kerhoas@hw.ac.uk.
Linda MarriottSchool of Engineering and Physical Sciences, Heriot-Watt University, UK. m.kersaudy-kerhoas@hw.ac.uk.
Nicholas R LeslieSchool of Engineering and Physical Sciences, Heriot-Watt University, UK. m.kersaudy-kerhoas@hw.ac.uk.ORCID http://orcid.org/0000-0001-5131-0541
Deborah WilliamsonThe University of St Andrews, UK.ORCID http://orcid.org/0000-0001-7363-6665
Thomas TranVictorian Infectious Diseases Reference Laboratory at the Peter Doherty Institute for Infection and Immunity, Royal Melbourne Hospital, Australia.
Chuan Kok LimVictorian Infectious Diseases Reference Laboratory at the Peter Doherty Institute for Infection and Immunity, Royal Melbourne Hospital, Australia.ORCID http://orcid.org/0000-0002-2828-2922
Maïwenn Kersaudy-KerhoasSchool of Engineering and Physical Sciences, Heriot-Watt University, UK. m.kersaudy-kerhoas@hw.ac.uk.ORCID http://orcid.org/0000-0002-8185-8230

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Timely and accurate nucleic acid extraction is a critical bottleneck in point-of-care (POC) molecular diagnostics, particularly for low-abundance cell-free nucleic acids (DNA, RNA, miRNA) in plasma. We present a fully finger-actuated microfluidic device for power-free, pipette-free, nucleic acid extraction. The prototype device integrates finger-actuated valves, pump and blister reagent storage, enabling a complete, intuitive, "sample-to-eluate" workflow, including lysis, binding, washing and elution

Indexed as

Cell-Free Nucleic AcidsLab-On-A-Chip DevicesMicrofluidic Analytical TechniquesPoint-of-Care SystemsEquipment DesignHumansRapid Diagnostic TestsCell-Free Nucleic Acids

Identifiers

PMID42627029
PMCPMC13660751

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.