DNA-Peptide Crosslinks Placed at Codon 249 of the p53 Tumor Suppressor Gene Induce G to A Transitions in Human Cells.

Priscilla Yawson, Jan Henric T Bacurio, Honnaiah Vijay Kumar, Natalia Y Tretyakova, Ashis K Basu

Abstract read

In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Priscilla YawsonDepartment of Chemistry, University of Connecticut, Storrs, Connecticut, USA.

Jan Henric T BacurioDepartment of Chemistry, University of Connecticut, Storrs, Connecticut, USA.ORCID https://orcid.org/0000-0002-9780-7438

Honnaiah Vijay KumarDepartment of Medicinal Chemistry and the Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.

Natalia Y TretyakovaDepartment of Medicinal Chemistry and the Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-0621-6860

Ashis K BasuDepartment of Chemistry, University of Connecticut, Storrs, Connecticut, USA.ORCID https://orcid.org/0000-0001-7951-4984

Funding

DNA Protein Cross-Links:Cellular Effects and Repair MechanismsR01ES023350 · NIEHS · UNIVERSITY OF MINNESOTA · PI CAMPBELL, COLIN R, TRETYAKOVA, NATALIA Y · 2014 to 2023

$5.0M

NIEHS NIH HHS R01 ES023350NIEHS NIH HHS R01-ES023350

6 · The paper itself

Abstract

Anticancer nitrogen mustard drugs including cyclophosphamide, mechlorethamine and chlorambucil induce covalent DNA-protein cross-links (DPCs) by sequentially alkylating the N7 position of guanine in DNA and amino acid residues within proteins. In cells, DPCs are proteolytically processed to yield corresponding peptide-DNA cross-links (DpCs), allowing polymerase bypass. In this study, site-specific, hydrolytically stable DNA lesions resembling nitrogen mustard-induced DpCs were generated via oxime ligation of an 11-mer peptide derived from histone H4 (NH

Indexed as

CodonCross-Linking ReagentsDNAGuaninePeptidesTumor Suppressor Protein p53DNA DamageDNA-Directed DNA PolymeraseHumansTranslesion DNA SynthesisCodonCross-Linking ReagentsDNADNA-Directed DNA PolymeraseGuaninePeptidesTumor Suppressor Protein p53DNA damageDNA–protein crosslinksmutationspolymerase bypasstumor suppressor gene

Identifiers

PMID42627024

DOI10.1002/cbic.70507

PMCPMC13495116

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.