ArticleJournal of clinical microbiology2026
A pseudovirus-based neutralizing antibody assay for measuring neutralizing antibody against rabies virus.
Article in Journal of clinical microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
11 authors.
Funding
Abstract
To establish a laboratory detection assay for a human neutralizing antibody (NAb) against rabies virus and to evaluate its efficiency in human serum samples. A pseudovirus pXN2‑RABV‑G harboring the RABV G gene was applied. The precision, robustness, linearity, stability, inclusivity, and limit of detection of the assay were evaluated. The consistency and correlation of the assay with ELISA and rapid fluorescent focus inhibition test (RFFIT) were analyzed. A pseudovirus-based neutralizing antibody (pVNA) detection system based on the pXN2‑RABV‑G was successfully developed and showed broad robustness (culture media: IMPORTANCE: Rabies is a lethal disease with no effective clinical treatment. Vaccination is the only way to prevent it routinely, which makes post-vaccination antibody testing essential. The current standard test requires a highly equipped laboratory, biosafety measures, and is time-consuming. This study develops a safe, efficient test for detecting rabies neutralizing antibodies using pseudovirus technology. It is comparable to the gold standard test in accuracy but easier to implement in routine labs, which enables broader use in screening and monitoring antibodies post-vaccination. This advantage addresses a key gap in rabies prevention, reducing the uncertainty for individuals with immunodeficiency who are nonresponsive to vaccination and at risk of rabies exposure.
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