ArticleJournal of neurological surgery. Part B, Skull base2026
Proton Versus Photon Radiation Therapy for Nasopharyngeal Carcinoma.
Article in Journal of neurological surgery. Part B, Skull base, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Objectives: Local treatment for nasopharyngeal carcinoma (NPC) commonly entails a regimen of radiotherapy. Due to its proximity to critical neurovascular structures, radiotoxicity presents a challenge. Proton radiotherapy (PRT) is associated with reduced toxicity and shows promise as an alternative to photon radiotherapy (XRT). Herein, we evaluated the therapeutic efficacies of PRT and XRT in NPC patients. Study Design: Retrospective database study. Methods: The 2004-2017 National Cancer Database was queried for patients with NPC who were treated with PRT or XRT. Using propensity score matching (PSM), patients who received XRT were matched in demographics and clinical characteristics with those who received PRT. Overall survival (OS) was assessed with Cox proportional-hazards regression and Kaplan-Meier analysis. Results: Of 7,003 patients (6,953 XRT, 50 PRT), 1,946 (27.8%) were female with a mean age of 55.7 ± 14.0 years. PSM resulted in 96 patients, with a large representation of T4 (57.3%), M0 (91.7%), and WHO type I (54.2%) tumors. Patients who underwent PRT were, on average, farther away from their treatment facility than XRT patients (101.7 versus 14.0 miles; Conclusion: NPC patients demonstrated higher OS following PRT compared with XRT. Prospective trials consisting of larger and more heterogeneous patient populations are warranted to better delineate the therapeutic efficacy of PRT and direct its appropriate use as a primary radiation modality for NPC patients.
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