Evidence map›Paper›PMID 42626728›Full record

ArticleStructural dynamics (Melville, N.Y.)2026

Slowly exchanging bound states of SARS-CoV-2 3CL

Anna De Falco, Ben Shurina, Rebecca Greene-Cramer, Theresa A Ramelot, Gaetano T Montelione

Abstract read
In one paragraph

Article in Structural dynamics (Melville, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anna De FalcoDepartment of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.ORCID https://orcid.org/0000-0001-9549-2711
Ben ShurinaDepartment of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.ORCID https://orcid.org/0000-0003-2407-9617
Rebecca Greene-CramerDepartment of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.ORCID https://orcid.org/0000-0002-5967-1402
Theresa A RamelotDepartment of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.ORCID https://orcid.org/0000-0002-0335-1573
Gaetano T MontelioneDepartment of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.ORCID https://orcid.org/0000-0002-9440-3059

Funding

Hybrid Methods for Dynamic Structure Analysis of Proteins from Pathogenic MicroorganismsR35GM141818 · NIGMS · RENSSELAER POLYTECHNIC INSTITUTE · PI MONTELIONE, GAETANO T · 2021 to 2025
$3.3M
Regional 800 MHz NMR System UpgradeS10OD030482 · OD · RENSSELAER POLYTECHNIC INSTITUTE · PI MONTELIONE, GAETANO T · 2021 to 2021
$1.3M
Orbitrap Eclipse Tribrid Mass Spectrometer as a Regional ResourceS10OD032168 · OD · RENSSELAER POLYTECHNIC INSTITUTE · PI ZHANG, FUMING · 2023 to 2023
$1.2M
NIGMS NIH HHS R35 GM141818NIH HHS S10 OD030482NIH HHS S10 OD032168
6 · The paper itself

Abstract

The SARS-CoV-2 virus causes COVID-19, and several of its gene products have been successfully targeted for antiviral drug development, including the 3C-like protease (3CL

Identifiers

PMID42626728
PMCPMC13493197

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.