Evidence map›Paper›PMID 42626704›Full record

ArticleJournal of neurological surgery. Part B, Skull base2026

Sinonasal and Skull Base Morbidity from a Modified Nasoseptal Flap versus No Flap in Pituitary Surgery.

Ash Li Khoo, Kachorn Seresirikachorn, Gretchen M Oakley, Henry P Barham, Jessica W Grayson, Carolyn Orgain, Raquel Alvarado, João Mangussi-Gomes, Larry H Kalish, Raewyn G Campbell and 1 more

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Article in Journal of neurological surgery. Part B, Skull base, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ash Li KhooRhinology and Skull Base Research Group, Applied Medical Research Centre, University of New South Wales, Sydney, New South Wales, Australia.
Kachorn SeresirikachornRhinology and Skull Base Research Group, Applied Medical Research Centre, University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000-0002-0158-7638
Gretchen M OakleyDivision of Otolaryngology - Head and Neck Surgery, Department of Surgery, University of Utah, Salt Lake City, Utah, United States.
Henry P BarhamRhinology and Skull Base Research Group, Baton Rouge General Medical Center, Baton Rouge, Louisiana, United States.
Jessica W GraysonDepartment of Otolaryngology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, United States.ORCID 0000-0002-2131-8005
Carolyn OrgainDivision of Otolaryngology, Head and Neck Surgery, Department of Surgery, University of Vermont Larner College of Medicine, Burlington, Vermont, United States.ORCID 0000-0002-6331-1485
Raquel AlvaradoRhinology and Skull Base Research Group, Applied Medical Research Centre, University of New South Wales, Sydney, New South Wales, Australia.
João Mangussi-GomesRhinology and Skull Base Research Group, Applied Medical Research Centre, University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000-0002-9441-1489
Larry H KalishRhinology and Skull Base Research Group, Applied Medical Research Centre, University of New South Wales, Sydney, New South Wales, Australia.
Raewyn G CampbellRhinology and Skull Base Research Group, Applied Medical Research Centre, University of New South Wales, Sydney, New South Wales, Australia.
Richard J HarveyRhinology and Skull Base Research Group, Applied Medical Research Centre, University of New South Wales, Sydney, New South Wales, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Durable sellar reconstruction and preserving sinonasal function are pivotal objectives in endoscopic pituitary surgery. Objective: This study aimed to investigate the postoperative skull base and sinonasal morbidity associated with a modified nasoseptal flap (NSF) in endoscopic pituitary surgery. Methods: A retrospective cohort study was conducted on patients undergoing endoscopic transsphenoidal pituitary surgery with either an NSF or non-NSF reconstruction of the sella. Patients had an obvious or suspected intraoperative cerebrospinal leak. A minimum 6-month follow-up was required. Outcome measures included postoperative skull base morbidity (cerebrospinal fluid leak, flap necrosis, pneumocephalus, meningitis, other intracranial infections, intracranial hemorrhage), sinonasal morbidity (epistaxis, crusting, sinus infection, atrophic rhinitis, persistent crusting, sinus dysfunction, mucocele formation, septal perforation), and patient-reported outcome measures (Sinonasal Outcome Test 22 [SNOT22; range 0-110], Nasal Symptom Score [NSS; range 0-30], and olfactory dysfunction score [range 0-5]). Results: About 372 patients (age 53.8 ± 16.7 years, 53.5% female) were included. Most patients underwent NSF reconstruction (87.1%). There was no significant difference in skull base morbidity between the NSF and non-pedicle flap groups. The NSF group had fewer self-reported sinus infections (0.9% vs. 6.4%, Conclusion: Utilizing a modified NSF in endoscopic transsphenoidal pituitary surgery allows for a sellar reconstruction option without detrimental impact on sinonasal function.

Indexed as

morbiditynasoseptal flappituitary surgerysinonasalskull base

Identifiers

PMID42626704
PMCPMC13493166

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.