SynthesisFrontiers in nutrition2026
Lifestyle interventions targeting adiposity in adults with psoriasis: a systematic review and network meta-analysis.
Synthesis in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Objective: Excess adiposity drives inflammation and impairs treatment response in psoriasis. We compared the effectiveness of dietary energy restriction, aerobic exercise, and combined diet-exercise interventions in adults with psoriasis and overweight or obesity. Methods: We searched four English- and four Chinese-language databases from inception to 15 January 2026 for randomized controlled trials of low-energy diet (LED), aerobic exercise (AE), diet plus aerobic exercise (D+AE), or usual care (UC). Primary outcomes were body mass index (BMI), body weight, and waist circumference; secondary outcomes included Psoriasis Area and Severity Index (PASI). A Bayesian random-effects network meta-analysis was performed with UC as the reference; certainty of evidence was assessed with Confidence in Network Meta-Analysis (CINeMA). Results: Nine trials (1,066 participants) were included. Versus UC, LED produced the most consistent reductions in BMI (mean difference -2.89 kg/m Conclusion: Low-energy diet showed the most consistent short-term reductions in BMI and body weight, whereas effects on waist circumference and PASI remained uncertain. Given the sparse network and low certainty of evidence, comparisons between lifestyle strategies should be regarded as hypothesis-generating rather than confirmatory. Systematic review registration: www.crd.york.ac.uk/prospero, CRD420261291403.
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