CircMETTL3 Inhibits H

Xiangyang Xin, Xin Zhao, Feng Ling, Liru Qin, Xinyue Liu, Changhe Liu

Abstract read

In one paragraph

Article in Journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

CircMETTL3 Inhibits HJournal of ophthalmology · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiangyang XinDepartment of Ophthalmology, Baotou Central Hospital, Baotou 014040, Inner Mongolia, China, btzxyy.com.ORCID https://orcid.org/0000-0002-0619-5318

Xin ZhaoDepartment of Ophthalmology, The Third Affiliated Hospital of Inner Mongolia Medical University (Inner Mongolia Baogang Hospital), Baotou 014010, Inner Mongolia, China.ORCID https://orcid.org/0000-0002-0082-0338

Feng LingTianjin Key Laboratory of Retinal Functions and Diseases, Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China, tmuec.com.

Liru QinDepartment of Ophthalmology, The Third Affiliated Hospital of Inner Mongolia Medical University (Inner Mongolia Baogang Hospital), Baotou 014010, Inner Mongolia, China.

Xinyue LiuDepartment of Ophthalmology, The Third Affiliated Hospital of Inner Mongolia Medical University (Inner Mongolia Baogang Hospital), Baotou 014010, Inner Mongolia, China.

Changhe LiuDepartment of Ophthalmology, The Third Affiliated Hospital of Inner Mongolia Medical University (Inner Mongolia Baogang Hospital), Baotou 014010, Inner Mongolia, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Age-related macular degeneration (AMD) is a common degenerative eye disease that eventually leads to irreversible vision loss. CircRNAs have received increasing attention for their regulatory role in AMD. In this study, whole transcriptome sequencing identified differentially expressed circRNA (circMETTL3) in AMD. Previous studies have unlocked the potential mechanism of circMETTL3 in cancer, but its role in AMD has not been studied. Methods: ARPE-19 cells treated with H Results: CircMETTL3 was revealed to decrease in AMD cell models. The addition of circMETTL3 decreased SA-β-gal staining and ROS production and facilitated cell viability in H Conclusions: In sum, these findings demonstrated that the circMETTL3/miR-100/BMPR2 axis plays a vital regulatory role in AMD development.

Indexed as

ARPE-19 cellsBMPR2circMETTL3H2O2miR-100

Identifiers

PMID42626541

DOI10.1155/joph/3194421

PMCPMC13492049

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.