ArticleNeuro-oncology advances
Hypothalamic obesity following craniopharyngioma surgery: What is the role of hypothalamic T2 signal changes in brain MRI?
Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Quality of life, morbidity, mortality, and long-term prognosis after craniopharyngioma.Frontiers in endocrinology · 2026Review
- Hunger, satiety, and eating behavior after craniopharyngioma - narrative review on current management and future therapeutic perspectives.Frontiers in endocrinology · 2026Review
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Authors and funding
11 authors.
Funding
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Abstract
Background: Despite hypothalamus-sparing surgical techniques, hypothalamic obesity remains common in childhood craniopharyngioma (cCP) survivors. Emerging evidence suggests a role for hypothalamic inflammation (HI) in obesity development. This study aimed to quantitatively assess post-operative T2 signal intensity (SI) changes, suggestive of inflammation and edema, using MRI and investigate its association with clinical outcomes, including BMI changes, over a 1-year period. Methods: We retrospectively analyzed 2 cCP cohorts. Diagnostic and post-operative MRIs were evaluated for changes in hypothalamic T2 SI on FLAIR. We assessed clinical and radiological predictors of post-operative T2 SI and examined correlations between ΔT2SI and ΔBMI Results: Both left ( Conclusion: Our data suggest that hypothalamic T2 SI increase is associated with the BMI increase and hypothalamic dysfunction after cCP surgery. These insights enhance our understanding of the pathophysiology underlying post-operative hypothalamic obesity and may inform future preventive and therapeutic strategies.
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