Evidence map›Paper›PMID 42626463›Full record

ArticleCase reports in gastroenterology

Adult-Onset Hyperammonemia: Case Report and Review of Literature.

Zehra Naseem, Amala Alenchery, Sarah Yuann Kim, Omar T Sims, Kadakkal Radhakrishnan, Sobia Nasir Laique

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PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zehra NaseemDepartment of Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA.
Amala AlencheryDivision of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Sarah Yuann KimCase Western Reserve University School of Medicine, Cleveland, OH, USA.
Omar T SimsDepartment of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic Foundation, Cleveland, OH, USA.
Kadakkal RadhakrishnanCase Western Reserve University School of Medicine, Cleveland, OH, USA.
Sobia Nasir LaiqueDepartment of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic Foundation, Cleveland, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Hyperammonemia is a life-threatening condition most associated with liver disease, though non-cirrhotic causes are increasingly recognized. Case Presentation: We report an 18-year-old female presenting with 1 week of progressive confusion, abdominal pain, and nausea. Initial evaluation showed normal routine laboratories but markedly elevated ammonia and respiratory alkalosis. She rapidly deteriorated, requiring intubation and intensive care. Ammonia peaked at 795 µg/dL and improved rapidly after urgent venous hemofiltration and medical therapy, with full neurological recovery by day 3. Further testing revealed late-onset ornithine transcarbamylase deficiency. Conclusion: We present an algorithm for the approach to hyperammonemia and urea cycle disorders through a comprehensive review of current diagnostic and therapeutic strategies pertaining to urea cycle disorders.

Indexed as

Case reportEncephalopathyHyperammonemiaLiver transplantNon-cirrhotic causesUrea cycle disorder

Identifiers

PMID42626463
PMCPMC13493119

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.