ArticleWorld journal of clinical pediatrics2026
Modality matters: Effect of dialysis modality on soluble intercellular adhesion molecule-1 in children on regular hemodialysis.
Article in World journal of clinical pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundIntercellular adhesion molecule-1 (ICAM-1) plays a key role in mediating leukocyte adhesion and endothelial injury. Elevated circulating levels of soluble ICAM-1 (sICAM-1) in patients undergoing hemodialysis (HD) have been linked to a higher incidence of cardiovascular complications.
aimTo evaluate the impact of dialysis modality and membrane performance on post-dialysis sICAM-1 levels in children undergoing maintenance HD.
methodsThis study included 26 children on low-flux HD for at least 3 months and 26 sex-matched and age-matched healthy controls. Patients were shifted to high-flux HD for 3 months, then subsequently to post-dilutional online hemodiafiltration (OL-HDF) for additional 3 months. At the end of each study phase, blood samples were obtained before and after a mid-week HD session for sICAM-1 measurement. To account for hemoconcentration, post-session ICAM-1 were hematocrit-adjusted using van Beaumont's formula yielding corrected ICAM-1 (cICAM-1).
resultsCirculating post-dialysis cICAM-1 levels increased significantly after low-flux HD compared with the corresponding pre-dialysis levels (
conclusionChildren on maintenance HD exhibit elevated sICAM-1 levels. Our findings suggest that higher-efficiency dialysis modalities, such as OL-HDF, may attenuate dialysis-related inflammation and endothelial activation in these patients.
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