ArticleWorld journal of clinical pediatrics2026
Vardenafil efficacy for the treatment of persistent pulmonary hypertension of the newborn.
Article in World journal of clinical pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPersistent pulmonary hypertension of the newborn (PPHN) remains a challenging condition with high morbidity and mortality despite advancements in management, which implies the need to investigate new therapies. While sildenafil is the drug of choice in resource-limited centers and for patients unresponsive to inhaled nitric oxide, alternative phosphodiesterase-5 inhibitors like vardenafil may offer superior efficacy.
aimTo assess the efficacy of vardenafil in the management of persistent pulmonary hypertension in newborns.
methodsThis randomized, double-blind, controlled, parallel clinical trial was conducted at Children's Hospital, Damascus University. Fifty-five newborns (32 females and 23 males, < 96 hours old) with moderate to severe PPHN were allocated at a 1:2 ratio to receive 2 mg/kg/day oral sildenafil (
resultsThe vardenafil group showed more rapid improvement. Pulmonary hypertension decreased significantly in the vardenafil group after 1 and 2 days (
conclusionVardenafil at 0.4 mg/kg/day has superior efficacy compared with sildenafil at 2 mg/kg/day in improving echocardiographic and clinical outcomes in patients with PPHN, with comparable safety profiles. These findings suggest vardenafil may be a valuable option for PPHN management.
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