Evidence map›Paper›PMID 42626106›Full record

ArticleBioengineering & translational medicine2026

Rapid, expression-free bacteriophage-based specific detection of target bacteria by conditional release of encapsidated reporter molecules.

Ákos Avramucz, Joseph P Wheatley, Sahan B W Liyanagedera, Tamás Fehér, Richard Amaee

Abstract read
In one paragraph

Article in Bioengineering & translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ákos AvramuczSynthetic and Systems Biology Unit, Institute of Biochemistry HUN-REN Biological Research Centre Szeged Hungary.
Joseph P WheatleySchool of Engineering University of Warwick Coventry UK.
Sahan B W LiyanagederaSchool of Engineering University of Warwick Coventry UK.ORCID https://orcid.org/0000-0002-9593-5487
Tamás FehérSynthetic and Systems Biology Unit, Institute of Biochemistry HUN-REN Biological Research Centre Szeged Hungary.ORCID https://orcid.org/0000-0001-9318-3640
Richard AmaeeLucidix Biolabs Chesham, Bucks UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rapid diagnosis of infectious diseases is of paramount importance to prevent or control outbreaks and pandemics. Detection of bacteria is commonly performed using culture-based and molecular detection methods, which cannot address the need for quick, specific and cheap diagnostics. Bacteriophage-based assays rely on the rapidity, specificity, contaminant-tolerance and effectiveness of phage-host interactions and can be engineered with fluorescence or luminescence-based reporters. Previous attempts, however, required transcription and translation of reporter genes, leading to long assays and restrictive protocols. Here, we shortened the signal generation time by detecting the injection of a phage protein, thereby circumventing the need for gene expression altogether. In our model diagnostic assay, we demonstrate that injection of the N-terminal fragment of the split nanoluciferase protein of

Indexed as

bacteriophage‐based diagnosticscapsid‐contained reporter proteinEscherichia coli K1luminescence assay

Identifiers

PMID42626106
PMCPMC13490980

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.