SynthesisFrontiers in endocrinology2026
A systematic review and meta-analysis on impulse-control disorders in patients with pituitary adenomas exposed to dopamine agonists.
Synthesis in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Background: Patients exposed to dopamine agonists (DAs) may develop impulse-control disorders (ICDs), as shown in Parkinson's Disease. Patients with pituitary adenomas treated with DAs may also have a higher frequency of ICDs. Objective: We compared the frequency of ICDs or impulsiveness in patients with pituitary adenomas treated with DAs versus patients with pituitary adenomas not exposed to DAs or healthy controls. Methods: Observational studies published in any language up to June 30 Results: Out of 14 studies identified, 10 reported the association between DAs and ICDs, and 6 reported the impact on the Barratt Impulsiveness Scale. DAs were significantly associated with ICDs (random-effects models, OR, 95% CI: 2.39, 1.78-3.21; I Conclusion: Patients with pituitary adenomas treated with DAs showed a higher frequency of ICDs. Studies to confirm these findings and investigate the risk factors for ICDs in this patient population are warranted.
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