Evidence map›Paper›PMID 42626026›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)

Real-world determinants of time to initiation of anti-amyloid treatments: comparative data from private and academic practice settings.

Varun Mehta, Divya Singh, Jordyn Kelman, Saanvi Nimma, Helen Lutz, Andrea Schnee, David Weisman, Michael H Rosenbloom

Abstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Varun MehtaMemory and Brain Wellness Center University of Washington Seattle Washington USA.
Divya SinghMemory and Brain Wellness Center University of Washington Seattle Washington USA.
Jordyn KelmanAbington Neurological Associates Abington Pennsylvania USA.
Saanvi NimmaAbington Neurological Associates Abington Pennsylvania USA.
Helen LutzAbington Neurological Associates Abington Pennsylvania USA.
Andrea SchneeMemory and Brain Wellness Center University of Washington Seattle Washington USA.
David WeismanAbington Neurological Associates Abington Pennsylvania USA.
Michael H RosenbloomMemory and Brain Wellness Center University of Washington Seattle Washington USA.ORCID https://orcid.org/0000-0001-7411-4172

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEarlier anti-amyloid therapy (AAT) initiation results in improved clinical outcomes in Alzheimer's disease (AD). We sought to identify demographic, clinical, and disease-related factors impacting door-to-treatment times (DTTs).

methodsA retrospective review of AAT data was conducted at private and academic neurological practices.

resultsA total of 329 patients (53.2% from private versus 46.8% academic practices), mean age 73.5 ± 7.2 (55.3% female), with most being non-Hispanic White were treated with lecanemab (81.2%) or donanemab (18.2%). DTTs were significantly reduced ( DISCUSSION: Patients with private insurance may experience greater delay in DTT, whereas BBBs may reduce DTT relative to traditional confirmatory biomarkers. DTT improves with clinic experience.

Indexed as

anti‐amyloid therapyblood‐based biomarkersdonanemabdoor to treatmentlecanemab

Identifiers

PMID42626026
PMCPMC13490854

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.