Evidence map›Paper›PMID 42625966›Full record

ReviewCurrent bladder dysfunction reports2026

Psychological and Behavioral Contributors to Lower Urinary Tract Dysfunction: Trauma, Stress, and Neurobiological Pathways.

Alexandra Neumann, Julianna Longo, Elise J B De, Andrew Schrepf, Anna Grace Kelly, Lindsey C McKernan

Abstract readReview
In one paragraph

Review in Current bladder dysfunction reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexandra NeumannFaculty of Medicine, Semmelweis University, Üllői út 26, Budapest, 1085 Hungary.ORCID 0009-0004-5120-2849
Julianna LongoDepartment of Psychiatry & Behavioral Sciences, Vanderbilt University School of Medicine, 47 New Scotland Avenue, Albany, NY 12208 USA.
Elise J B DeDepartment of Urology, Albany Medical College, 3401 West End Ave #380, Nashville, TN 37203 USA.ORCID 0000-0003-0730-9038
Andrew SchrepfDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, USA.ORCID 0000-0003-4291-0320
Anna Grace KellyDepartment of Psychiatry & Behavioral Sciences, Vanderbilt University School of Medicine, 47 New Scotland Avenue, Albany, NY 12208 USA.ORCID 0000-0001-6313-1233
Lindsey C McKernanDepartment of Psychiatry & Behavioral Sciences, Vanderbilt University School of Medicine, 47 New Scotland Avenue, Albany, NY 12208 USA.ORCID 0000-0001-9419-8502

Funding

Mechanistic-Based Treatment of Interstitial Cystitis/Bladder Pain SyndromeR01DK133415 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lindsey Colman McKernan · 2023 to 2026
$2.9M
Central Sensitization and Psychosocial Impacts on Overactive BladderR01DK128293 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MCKERNAN, LINDSEY COLMAN, SEBESTA, ELISABETH M · 2021 to 2024
$2.0M
Stress and Anxiety Effects on Overactive Bladder: A Controlled StudyR01DK129624 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MCKERNAN, LINDSEY COLMAN, SEBESTA, ELISABETH M · 2021 to 2025
$2.0M
NIDDK NIH HHS R01 DK128293NIDDK NIH HHS R01 DK129624NIDDK NIH HHS R01 DK133415
6 · The paper itself

Abstract

Purpose of Review: Chronic pelvic pain and lower urinary tract dysfunction are associated with a high prevalence of depression, anxiety, trauma history, and stress-related disorders, with worsening of symptoms in these groups. This review characterizes the mechanisms behind these associations and the benefits of intervention. Recent Findings: Trauma, stress, and neurobiological pathways interact as psychological and behavioral contributors to lower urinary tract symptoms and pelvic pain. The immune system and the neuraxis share pathways in chronic pain as it relates to stress regulation in urologic populations, with implications for symptom presentation. Trauma, including early life adverse experiences and later diverse stressors, can potentiate these pathways. Summary: Co-occurrence of psychological factors with incontinence, retention, urinary urgency, frequency, nocturia, and bladder pain is common and clinically relevant to the urologist. Psychological interventions have been demonstrated to improve both quality of life and the symptoms themselves in concert with standard organ-based treatment approaches.

Indexed as

Chronic pelvic painInflammationInterstitial cystitisNeurobiologyStressTraumaVoiding dysfunction

Identifiers

PMID42625966
PMCPMC13490219

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.