A Case of Suspected Multiple Acyl-CoA Dehydrogenase Deficiency-Induced Encephalopathy.

Molly Hirsh, Lauren McCroskie, Julia Weaver, Kathryn Humes, Nicola M Zetola

Abstract read

In one paragraph

Article in Case reports in critical care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

A Case of Suspected Multiple Acyl-CoA Dehydrogenase Deficiency-Induced Encephalopathy.Case reports in critical care · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Molly HirshAugusta University/University of Georgia Medical Partnership, Athens, Georgia, USA.ORCID https://orcid.org/0009-0005-6816-5818

Lauren McCroskieMedical College of Georgia, Augusta, Georgia, USA, gru.edu.

Julia WeaverMedical College of Georgia, Augusta, Georgia, USA, gru.edu.

Kathryn HumesMedical College of Georgia, Augusta, Georgia, USA, gru.edu.ORCID https://orcid.org/0009-0005-3654-9286

Nicola M ZetolaMedical College of Georgia, Augusta, Georgia, USA, gru.edu.ORCID https://orcid.org/0000-0003-0712-8579

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple acyl-coenzyme A dehydrogenase deficiency (MADD) is a rare inherited disorder that disrupts fatty acid metabolism. We report a case of a patient who presented with confusion, undifferentiated shock, and rapidly worsening lactic acidosis and hyperammonemia, unexplained in severity by primary liver dysfunction. Metabolic investigations suggested the probable cause was late-onset MADD, likely triggered by pneumonia and exacerbated by early administration of fatty acid-containing sedatives. Early recognition of MADD and other metabolic disorders, whether inherited or acquired, is crucial for timely diagnosis and management. Unexplained hyperammonemia and other metabolic abnormalities should prompt clinicians to consider these rare conditions.

Indexed as

electron transfer flavoprotein dehydrogenaseglutaric aciduria Type IIhyperammonemialipid storage myopathyMADDmetabolic disordermultiple acyl-coenzyme A dehydrogenase deficiency

Identifiers

PMID42625916

DOI10.1155/crcc/9093349

PMCPMC13490339

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.