ArticleNAR cancer2026
RAD51C breast cancer-identified variants with attenuated homologous recombination function exhibit sensitivity to combined PARP1 and ATR inhibition.
Gayatri S Ganesan, Zoë R Moosbrugger, Phoebe S Parker, Noah J Goff, Arjun K Kumar, Kara A Bernstein
Abstract read
In one paragraphArticle in NAR cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
6 authors.
Gayatri S GanesanDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104,United States.
Zoë R MoosbruggerDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104,United States.
Phoebe S ParkerDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104,United States.
Arjun K KumarDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104,United States.
Funding
UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert H. Vonderheide · 1985 to 2026
$222.3MTranslational Research Training Program in Environmental Health SciencesT32ES019851 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Kara A Bernstein, Trevor M Penning · 2012 to 2026
$6.0MReplication fork dynamics and repair by Rad51 paralogues after DNA alkylationR01ES030335 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Kara A Bernstein · 2019 to 2026
$2.9MRAD51 paralog function in cancer predisposition and genome integrity R01ES031796 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BERNSTEIN, KARA A · 2021 to 2025
$2.2MNCI NIH HHS P30 CA016520NIEHS NIH HHS R01 ES030335NIEHS NIH HHS R01 ES031796NIEHS NIH HHS T32 ES019851
6 · The paper itselfAbstract
Indexed as
Ataxia Telangiectasia Mutated ProteinsBreast NeoplasmsDNA-Binding ProteinsHomologous RecombinationPoly (ADP-Ribose) Polymerase-1Cell Line, TumorFemaleHumansPhthalazinesPoly(ADP-ribose) Polymerase InhibitorsAtaxia Telangiectasia Mutated ProteinsATR protein, humanDNA-Binding ProteinsPARP1 protein, humanPhthalazinesPoly (ADP-Ribose) Polymerase-1Poly(ADP-ribose) Polymerase InhibitorsRAD51C protein, human
Identifiers
PMID42625895
PMCPMC13490947
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