Evidence map›Paper›PMID 42625807›Full record

ArticleResearch (Washington, D.C.)2026

PDHA1 Hyperactivation Orchestrates Metabolic Reprogramming Promoting Endothelial Senescence.

Wen-Jing Zhong, Nan-Shi-Yu Yang, Chen-Yu Zhang, Yu-Biao Liu, Ling Jin, An-Jun Ou, Hui Chen, Juan Li, Yong Zhou, Bai-Mei He and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wen-Jing ZhongDepartment of Geriatric Respiratory and Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Nan-Shi-Yu YangDepartment of Geriatric Respiratory and Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Chen-Yu ZhangDepartment of Physiology, Xiangya School of Basic Medical Sciences, Central South University, Changsha, Hunan 410078, China.
Yu-Biao LiuDepartment of Physiology, Xiangya School of Basic Medical Sciences, Central South University, Changsha, Hunan 410078, China.
Ling JinDepartment of Physiology, Xiangya School of Basic Medical Sciences, Central South University, Changsha, Hunan 410078, China.
An-Jun OuDepartment of Physiology, Xiangya School of Basic Medical Sciences, Central South University, Changsha, Hunan 410078, China.
Hui ChenDepartment of Physiology, Xiangya School of Basic Medical Sciences, Central South University, Changsha, Hunan 410078, China.
Juan LiDepartment of Physiology, Xiangya School of Basic Medical Sciences, Central South University, Changsha, Hunan 410078, China.
Yong ZhouDepartment of Physiology, Xiangya School of Basic Medical Sciences, Central South University, Changsha, Hunan 410078, China.
Bai-Mei HeDepartment of Geriatric Respiratory and Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Jia-Xi DuanDepartment of Geriatric Respiratory and Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.ORCID https://orcid.org/0000-0002-7113-8109

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While recent studies have established links between metabolic reprogramming and inflammatory senescence, the specific metabolic drivers in vascular aging remain incompletely defined. Here, we systematically characterized senescent phenotypes and targeted metabolomic profiles in primary aging endothelial cells, identifying a pyruvate dehydrogenase E1 component subunit alpha (PDHA1)-dependent metabolic shift as a hallmark of cellular senescence. Using a D-galactose-induced senescence model, we demonstrated that endothelial-specific

Identifiers

PMID42625807
PMCPMC13490744

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.